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For patients with long-standing poorly controlled type 2 diabetes mellitus on metformin plus a sulfonylurea

Exenatide, Pioglitazone Effective for Poorly Controlled T2DM

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Findings in patients with long-standing poorly controlled type 2 diabetes on metformin, sulfonylurea
Extending the market exclusivity for existing drugs that are granted subsequent U.S. Food and Drug Administration approval for a new rare disease indication would provide manufacturers with substantial compensation

Extending Rx Exclusivity Could Boost Study for Rare Diseases

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Substantial compensation to many drug manufacturers, especially for top-selling products
An experimental drug

Experimental Drug May Simplify Macular Degeneration Treatment

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Animal tests showed fewer injections needed to treat age-related macular degeneration
Men who have sex with men receiving antiretroviral therapy to treat HIV infection may be at increased risk for syphilis

Syphilis Risk May Be Higher in HIV Patients on Antiretrovirals

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Medications may raise susceptibility to bacterium that causes the sexually transmitted disease
Some systemic medication has a modest effect on intraocular pressure among Asian patients with glaucoma

Modest Links for Systemic Medication Use, IOP in Glaucoma

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Systemic β-blocker use linked to lower IOP; ACEI, ARB, statin, sulfonylurea linked to higher IOP
Cognitive co-activation is associated with a significantly smaller levodopa effect on resting tremor in Parkinson's disease

Cognitive Stress Reduces Levodopa Effect in Parkinson’s

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Levodopa effect significantly smaller during cognitive co-activation than during rest
Tetracycline combined with colchicine is effective for treatment of hidradenitis suppurativa

Tetracycline + Colchicine Effective in Hidradenitis Suppurativa

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Combination treatment effective for disease control with signs of improvement at three months
β-blockers are associated with significantly reduced mortality

β-Blockers Linked to Reduced Mortality in HFrEF, A-Fib

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Reduction in all-cause mortality, but not hospitalization, regardless of pattern, burden of a-fib
For patients with advanced midgut neuroendocrine tumors

177Lu-Dotatate Ups PFS in Midgut Neuroendocrine Tumors

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Longer progression-free survival compared to high-dose octreotide long-acting repeatable
The excessive regulatory regime at the U.S. Food and Drug Administration is an important driver of high drug prices

Excessive FDA Regulation Driving High Drug Prices

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First-in-class drugs are fast-tracked while follow-on drugs can take up to 15 years to be approved