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The prices of brand-name drugs used by many older Americans rose nearly 130 times faster than inflation last year

AARP: Medication Costs for Seniors Continue to Soar

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Cost of brand-name drugs for chronic conditions rose nearly 130 times faster than inflation rate
Outcomes-based pricing for novel and expensive biopharmaceuticals is supported in an Ideas and Opinions piece published online Dec. 13 in the Annals of Internal Medicine.

Outcomes-Based Pricing Suggested for New, Costly Drugs

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Strategy would compel manufacturers and insurers to share accountability for clinical outcomes
β-blockers may not be the medicine of choice for nursing home residents with dementia

β-Blockers May Not Be Appropriate for Dementia Patients

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In this group, use of drugs after acute myocardial infarction can compromise quality of life
One in six U.S. adults take a psychiatric medication to treat conditions such as depression

Rate of Psychiatric Drug Use About 16 Percent in U.S. Adults

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Highest rate of use seen for antidepressants
In women with advanced hormone receptor-positive

SABCS: Rx Combo Promising in Advanced HR+, HER2− Breast CA

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Everolimus added to fulvestrant appears to improve progression-free survival
Some high-risk women who take tamoxifen to prevent breast cancer may mistake naturally occurring nausea and vomiting for side effects of the drug and stop taking it

SABCS: Tamoxifen May Be Unfairly Blamed for Side Effects

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Perceived side effects might lead some to stop taking the medication, researchers say
Women taking aromatase inhibitors may show signs of early endothelial dysfunction that could lead to cardiovascular disease

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

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Women on aromatase inhibitors exhibit less elasticity in their blood vessels
Osimertinib is more effective than platinum-pemetrexed therapy in patients with T790M-positive advanced non-small-cell lung cancer whose disease has progressed during first-line epidermal growth factor receptor tyrosine kinase inhibitor treatment

Osimertinib Bests Platinum-Pemetrexed in T790M+ NSCLC

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Significantly longer duration of progression-free survival with osimertinib vs platinum-pemetrexed
An experimental drug for infants with spinal muscular atrophy type 1 appears to be effective

Nusinersen Shows Promise in Spinal Muscular Atrophy

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Study results are promising but do not represent a cure
Cardiac arrest patients who receive epinephrine within five minutes are more likely to survive than those who don't receive the drug within that time frame

Timely Epinephrine Increases Cardiac Arrest Survival

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Dose within five minutes of cardiac arrest increases chances by 20 percent