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For patients with rheumatoid arthritis

Little Benefit for Etanercept-MTX Before Triple Therapy in RA

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First-line etanercept-methotrexate would result in 0.15 additional lifetime QALY, at cost of $77,290
Two separate research groups say they've successfully reduced cholesterol in humans by using different methods to block the angiopoietin-like 3 (ANGPTL3) gene. The findings were published online May 24 in the New England Journal of Medicine.

Targeting ANGPTL3 Can Significantly Lower Cholesterol

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Two trials show promise for non-statin approach to cardiovascular disease prevention
Benralizumab is associated with a significant reduction in glucocorticoid doses among adults with severe asthma

ATS: Benralizumab Reduces Glucocorticoid Doses in Asthma

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Significant 75 percent reduction in median final oral glucocorticoid doses from baseline
For patients with vasodilatory shock that does not respond to high-dose vasopressors

ATS: Angiotensin II Improves BP in Vasodilatory Shock

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Angiotensin II effective for vasodilatory shock in patients not responding to conventional vasopressors
Patients with life-limiting illness often receive medications of questionable benefit given their remaining life span

Patients Often Prescribed Futile Drugs in Last Months of Life

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Researchers find many still prescribed long-term disease-preventing medications
Imatinib (Gleevec) may effectively treat severe refractory asthma

KIT Inhibition by Imatinib Helps Severe Refractory Asthma

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Improvement in airway hyperresponsiveness seen with imatinib versus placebo
Lower- and higher-dose elagolix are beneficial for women with endometriosis

Lower-, Higher-Dose Elagolix Beneficial for Endometriosis

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Higher percentage of women have clinical response for dysmenorrhea, non-menstrual pelvic pain
Capecitabine (Xeloda) may prolong survival in patients with biliary tract cancer

ASCO: Capecitabine May Extend Survival in Biliary Tract Cancer

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Survival benefit seen in those given capecitabine versus surgery alone
Use of phosphodiesterase type 5 inhibitors does not appear to increase the risk of melanoma

Researchers Say PDE5 Inhibitors Don’t Cause Melanoma

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Any connection appears to be due to detection bias, investigators conclude
Adverse effects are less frequent at lower doses of atropine

Findings Support Lower Doses of Atropine in Pediatric Myopia Rx

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Efficacy of atropine is independent of dose, while adverse effects are dose dependent