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The American Diabetes Association (ADA) recommends metformin as first-line therapy for type 2 diabetes

ADA Updates Standards of Medical Care in Diabetes

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Metformin should be initiated at the time of T2DM diagnosis unless there are contraindications
For patients with chronic hepatitis C treated with direct-acting antivirals

HBV Reactivation Seen With DAA Treatment of Chronic Hep C

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HBV virological reactivation in four of seven patients with current HBV infection; none with past infection
For patients with type 2 diabetes

Better Outcomes in T2DM With No Delay in Tx Intensification

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Greater reduction in HbA1c, but increased risk of severe hypoglycemia with no delay in intensification
For patients with type 2 diabetes

Vildagliptin, Metformin Have Different Effects on BP in T2DM

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Vildagliptin lowers BP, elevates HR, while metformin increases HR with no impact on BP
Use of ketamine for treatment of mood disorders should include appropriate patient selection and consideration of potential risks of treatment

Ketamine Beneficial for Certain Patients With Mood Disorders

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Available data on ketamine use are limited and risks should be considered before its use
Mental health patients are more likely to reject treatment if it involves only medication

Patients Reluctant to Comply With Drug-Only Psychiatric Treatment

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Compliance more likely when doctors prescribe psychotherapy, researchers find
Only 20 percent of patients with resistant hypertension take all the medicine they're prescribed

Few Patients With Resistant High BP Take Rx As Prescribed

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Failure to follow doctors' orders leads to unnecessary and costly treatment, researchers say
The anti-inflammatory biologic drug anakinra (Kineret) does not reduce fatigue severity in women with chronic fatigue syndrome

Anakinra Ineffective for Reducing Symptoms of Chronic Fatigue

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Anti-inflammatory biologic offered no meaningful decrease in fatigue severity
For patients with BRAF wild-type metastatic melanoma

Cost-Effectiveness Compared for Metastatic Melanoma Treatments

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First-line pembrolizumab or nivolumab followed by second-line ipilumumab most cost-effective
For patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL)

Blinatumomab Linked to Longer Survival in Adults With ALL

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Significantly longer overall, event-free survival for relapsed, refractory B-cell precursor ALL