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Sodium-glucose cotransporter 2 inhibitors appear to increase the risk of diabetic ketoacidosis in patients with type 2 diabetes

SGLT2 Inhibitors Linked to Increased Risk of Ketoacidosis

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Associated with approximately twice the risk of DKA compared to DPP4 inhibitors
Lithium is linked to an increased risk of heart malformations in infants born to women taking the drug during pregnancy

Lithium’s Risk to Fetus May Be Lower Than Previously Thought

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Increased risk of cardiac defects seen, but magnitude of effect smaller than previously postulated
Open-label placebos are associated with a positive effect compared with no treatment in a variety of clinical conditions

Positive Clinical Effects Seen for Placebos Without Deception

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Findings based on five studies involving patients with IBS, depression, allergic rhinitis, back pain, ADHD
From 2004 to 2015 there were decreases in the prevalence of advanced disease at initiation of antiretroviral therapy in 10 high-burden countries

Prevalence of Advanced HIV at ART Initiation Decreasing

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Decreases seen in Haiti, Mozambique, Namibia, Nigeria, Swaziland, Uganda, Vietnam, Zimbabwe
There is little agreement between the American Society of Clinical Oncology Value Framework and European Society for Medical Oncology Magnitude of Clinical Benefit Scale

ASCO: Agreement Lacking With ESMO on Most Effective Drugs

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Negative correlation identified for ASCO benefit score with monthly incremental drug costs
Two new medications that target specific genetic mutations may improve survival for patients with specific types of advanced non-small-cell lung cancer

ASCO: Novel Meds Show Promise in Advanced NSCLC

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Results presented from two phase III trials
Combining low doses of several different antihypertensive medications may be better than using a standard dose of just one drug

Combo of Several Meds at Smaller Doses May Boost HTN Care

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Researchers posit smaller doses of several drugs better than standard dose of just one medication
Free meals

ASCO: Industry Perks Influence Physicians’ Choice of Cancer Rx

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Even relatively small payments appear to make a difference, researchers say
Olaparib (Lynparza) monotherapy can provide a significant benefit over standard therapy in women with human epidermal growth factor receptor type 2-negative metastatic breast cancer and a germline BRCA mutation

ASCO: Olaparib Efficacious in BRCA-Related Breast Cancer

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May offer a new treatment for women with advanced BRCA-related disease, researchers say
In men with advanced prostate cancer

ASCO: Abiraterone Extends Survival in Metastatic Prostate CA

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Side effects noted with use of abiraterone similar to those already found in patients taking the drug