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Tag: Prescription Drugs

Nocebo hyperalgesia is stronger when an inert treatment is labeled as being an expensive medication rather than a cheap one

Stronger Nocebo Effect When Inert Rx Labeled As Expensive

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Neural interactions between cortex, brainstem, and spinal cord mediate this effect
Most cancer drugs that enter the market in Europe have no evidence of benefit for survival or quality of life

Most Cancer Drugs Approved in Europe Show No Survival Benefit

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Even in the postmarketing period, half of cancers have no evidence of significant survival gain
For patients with type 2 diabetes mellitus

Addition of DPP4i to AGI Reduces HbA1c in T2DM

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Greater drop in HbA1c with DPP4i added to alpha glucosidase inhibitor, with no increase in weight
Immediate or delayed differences in adverse event rates were seen after generic commercialization of three antihypertensive drugs

Commercialization of Generics Impacts Adverse Event Rates

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Adverse events up for generic users of losartan, valsartan, candesartan in month of commercialization
Nonvalvular atrial fibrillation patients who take non-vitamin K oral anticoagulants along with certain other medications are at increased risk for major bleeding

Anticoagulants With Other Drugs Raise Bleeding Risk in AF

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And antithrobotic medications linked to higher rate of hematuria-related events in older adults
Over the short term there is not a significantly increased overall cancer risk among individuals with type 2 diabetes using sodium-glucose cotransporter 2 inhibitors

Sodium-Glucose Cotransporter 2 Inhibitors Not Cancer Risk Factor

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Overall cancer risk not increased compared with placebo, other active glucose-lowering treatments
Secukinumab is safe and effective as a treatment for patients with extensive moderate-to-severe scalp psoriasis

Secukinumab Effective for Moderate/Severe Scalp Psoriasis

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Over half of patients have 90 percent improvement on Psoriasis Scalp Severity Index score
Fewer than half of patients prescribed PCSK9 inhibitors receive approval

About Half of Patients Receive Approval for PCSK9i Prescription

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Prescription abandonment linked to copay costs, with rates more than 75 percent for copays > $350
The majority of older patients are aware of medication harms

Few Older Patients Aware of Deprescribing

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Although the majority surveyed are aware of medication harms
Nonadherence to angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers and/or statins following acute myocardial infarction is associated with higher mortality

Nonadherence to Statins + ACEIs/ARBs Risky Post MI

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Adherence to beta-blockers may not be as beneficial to patients after myocardial infarction