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From 2002 to 2015 there was a substantial increase in gabapentinoid use

Increase Seen in Gabapentinoid Use From 2002 to 2015

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More than three-fold increase in percentage of adults using gabapentin and/or pregabalin
Across cancers

Out-of-Pocket Costs Correlate With Receipt of Cancer Care

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Across cancers, higher costs tied to higher rates of oral prescription abandonment, delayed initiation
More than one-third of patients with newly diagnosed epilepsy do not respond to treatment with antiepileptic drugs

More Than a Third of Patients Do Not Respond to Antiepileptics

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Overall, 89.9 percent of patients who achieve seizure control do so with first, second AED regimen
Rituximab treatment seems effective for systemic lupus erythematosus-associated immune cytopenias

Rituximab Effective for Lupus-Associated Cytopenia

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Overall initial response rate of 86 percent in 71 patients, with complete response for 60.5 percent
The reduction in risk of cardiovascular death with empagliflozin is most mediated by changes in hematocrit and hemoglobin

Plasma Volume Changes May Mediate Effects of Empagliflozin

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Findings suggest reduced CV mortality risk mediated by effects on markers of plasma volume
New evidence regarding safety is spurring the U.S. Food and Drug Administration to remove a Boxed Warning from certain inhaled medications used to treat asthma and chronic obstructive pulmonary disease.

FDA Removes Boxed Warning From Certain Asthma Medications

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Decision applies to long-acting beta agonists used in combination with inhaled corticosteroids
Methotrexate and azathioprine appear to be effective and safe as maintenance treatments in moderate-to-severe atopic dermatitis for up to five years

Methotrexate, Azathioprine Seem Safe Long-Term for Dermatitis

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For up to five years as maintenance treatments for moderate-to-severe atopic dermatitis
Compared to placebo

Pioglitazone Associated With Lower Blood Leptin in Diabetes

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In T2DM, leptin levels are lower with pioglitazone than placebo but not oral antidiabetic drugs
For patients undergoing catheter ablation for nonvalvular atrial fibrillation

Interruption of Apixaban Doesn’t Impact Bleeding in A-Fib

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Similarly low rate of thromboembolic events with uninterrupted, minimally interrupted apixaban
Varenicline is associated with reduced heavy drinking among men and with increased smoking abstinence

Varenicline Linked to Reduction in Heavy Drinking in Men

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Also associated with smoking abstinence in overall sample of participants