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Rituximab has better efficacy and lower discontinuation rates than other disease-modifying treatment choices for newly diagnosed relapsing-remitting multiple sclerosis

Rituximab Tops Other Disease-Modifying Tx Options in MS

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Better efficacy, lower discontinuation rate in newly diagnosed relapsing-remitting multiple sclerosis
The use of idalopirdine does not improve cognition versus placebo over 24 weeks of treatment for patients with mild-to-moderate Alzheimer's disease

Idalopirdine May Not Improve Cognition in Mild Alzheimer’s

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Findings from three randomized trials show no improvement in cognition vs. placebo over 24 weeks
A novel oral dosage form enables sustained release of antiretrovirals

Week’s Worth of HIV Meds in a Single-Dose Capsule Feasible

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Oral platform delivers three antiretrovirals for up to seven days after single administration
Fluorouracil application can reduce the risk of surgery for squamous cell carcinoma for one year among patients with a history of keratinocyte carcinomas

Fluorouracil Tied to Reduced Surgery for Squamous Cell CA

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Reduced risk of squamous cell carcinoma, but not basal cell carcinoma, for one year in at-risk veterans
Esketamine seems to be efficacious and safe for patients with treatment-resistant depression

Esketamine Safe, Effective for Treatment-Resistant Depression

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Change in Montgomery-Åsberg Depression Rating Scale score superior for esketamine versus placebo
Although patients with pre-existing autoimmune disease who receive checkpoint inhibitors (CPIs) are at risk for exacerbation of their disease

Immune-Related Adverse Events Up With Checkpoint Inhibitors

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Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy
For patients with chronic obstructive pulmonary disease

CVD Risk Up With β2-Agonist, Antimuscarinic Antagonist Start

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New use of long-acting β2-agonists, antimuscarinic antagonists tied to higher CVD risk in first 30 days
For patients with acute severe ulcerative colitis

Predictors of Infliximab Response in Ulcerative Colitis Identified

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Baseline Mayo Endoscopic Score, CRP/albumin ratio predict treatment response and risk for colectomy
Few modern

Few Immuno-Oncology Agents Reach ASCO Efficacy Thresholds

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Durable survival, response rates rarely recognized as significant by current oncology value frameworks
Pharmaceutical aids are not effective for increasing long-term smoking cessation

Pharmaceutical Aids Not Found to Be Helpful for Smoking Cessation

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No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence