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There have been small but significant reductions in the incidence and prevalence of benzodiazepine use in older adults in Canada

Benzodiazepine Use Declining in Older Adults

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Findings based on assessment of incidence, prevalence of use in three countries from 2010-2016
For critically ill adults at high risk of delirium

Haloperidol for Delirium in Critically Ill No Help for Survival

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Prophylactic haloperidol does not improve survival at 28 days compared with placebo in critically ill adults
For patients with moderate-to-severe hand pain and radiographic osteoarthritis

Hydroxychloroquine No Better Than Placebo for Hand OA

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No more effective than placebo for moderate-to-severe hand pain and radiographic osteoarthritis
Ustekinumab improves psoriasis and reduces vascular inflammation among patients with moderate-to-severe psoriasis

AAD: Ustekinumab Cuts Vascular Inflammation in Psoriasis

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Reduction in total aortic vascular inflammation with ustekinumab versus increase with placebo
For women with symptomatic uterine leiomyomas

Ulipristal Achieves Amenorrhea for Symptomatic Leiomyomas

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Ulipristal superior to placebo to achieve amenorrhea for bleeding due to symptomatic uterine leiomyomas
For adults with inadequately controlled type 2 diabetes

Ertugliflozin Tied to Improved Glycemic Control in T2DM

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Improvement in glycemic control, reduction in body weight, SBP; increase in genital mycotic infections
An automated central pharmacy system

Automated Central System Offers Time Savings for Pharmacists

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Cart-fill process using new automated system is more efficient, frees up time for other roles
Pimavanserin is efficacious at six weeks for patients with Alzheimer's disease psychosis but not at 12 weeks

Pimavanzserin Cuts Alzheimer’s Psychosis at Six Weeks

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Significantly greater reduction in NPI-NH psychosis score at 6 weeks versus placebo, but not at 12 weeks
The therapeutic significance of losartan in Marfan syndrome may lie in its ability to activate protective endothelial function

Losartan May Improve Endothelial Function in Marfan Syndrome

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Therapeutic importance may be increased in endothelial nitric oxide release, not ATR1 inhibition
For patients with acute coronary syndrome

Direct Oral Anticoagulants Plus Antiplatelets Effective in ACS

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Pronounced benefit for patients with STEMI, but no significant effect for patients with NSTE-ACS