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Using CYP2C19 genotype-guided dual antiplatelet therapy selection is feasible in a real-world setting

Genotype-Guided Antiplatelet Therapy Feasible, Effective

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Genotype-guided therapy improves outcomes among CYP2C19 intermediate, poor metabolizers
Outcomes-based pricing does not reduce the costs of proprotein convertase subtilisin/kexin type 9 inhibitors

Outcomes-Based Pricing Doesn’t Cut Costs of PCSK9 Inhibitors

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Incremental cost-effectiveness ratio for PCSK9 inhibitor improved marginally in three refund scenarios
For castration-resistant prostate cancer

Low-Dose Abiraterone Acetate Noninferior for Prostate Cancer

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Low-dose AA with low-fat breakfast had greater effect on PSA; similar effect to standard dose
Exposure to sodium valproate or a combination of antiepileptic drugs in utero is associated with worse attainment on national educational tests for 7-year-olds

Educational Attainment Down With In Utero Exposure to AEDs

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Exposure to sodium valproate, combo of antiepileptic drugs tied to worse attainment on national tests
Intravitreal anti-vascular endothelial growth factor treatment is not associated with increased risk of systemic adverse events for patients with neovascular age-related macular degeneration

Intravitreal Anti-VEGF Use Not Tied to Systemic Adverse Events

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Risk not up in neovascular age-related macular degeneration, diabetic macular edema
For patients with previously untreated clear-cell advanced renal-cell carcinoma

Nivolumab Plus Ipilimumab Tops Sunitinib for Advanced Renal CA

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Overall survival, objective response higher than sunitinib for untreated clear-cell advanced RCC
For patients with secondary progressive multiple sclerosis

Siponimod Cuts Risk of Disability Progression in Multiple Sclerosis

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Reduction in 3-month confirmed disability progression in secondary progressive multiple sclerosis
Dipeptidyl peptidase-4 inhibitors are associated with increased risk of inflammatory bowel disease among patients with type 2 diabetes

Dipeptidyl Peptidase-4 Inhibitors in T2DM Linked to IBD

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Higher risk of inflammatory bowel disease with longer use of dipeptidyl peptidase-4 inhibitor
Despite the popularity

Unique Risks Associated With Texting Medical Orders

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Institute of Safe Medication Practices indicates risks such as abbreviations, autocorrection
For patients with persistent asthma

Adjuvant Long-Acting Muscarinic Antagonist Improves Asthma

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Versus adjuvant placebo, LAMA or LABA plus inhaled corticosteroids lowers risk of asthma exacerbations