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Pharmaceutical vial fill volumes can be optimized to reduce drug wastage when dosing is calculated by patient weight or body surface area

Available Vial Sizes Can Cut Drug Waste in Weight-Based Dosing

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Vial preparation sizes can be optimized to reduce drug wastage, reduce costs
For patients with knee osteoarthritis and at least 12 months of follow-up

Effect Sizes Uncertain for Meds Versus Placebo in Knee OA

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Meta-analysis: large uncertainty versus placebo for all medications for pain relief
The lowest-priced generic drugs are more likely to experience shortages

Low-Priced Generic Drugs Most Likely to Have Shortages

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Shortages associated with modest increases in price, ranging from 6 to 14 percent
Incorrect prescribing alerts for psychotropic medications may be common

Incorrect Prescribing Alerts Common for Psychotropic Meds

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One-third with electronic Rx system that provides alerts believe system provides incorrect warnings
Sorafenib prolongs progression-free survival among patients with desmoid tumors

Sorafenib for Desmoid Tumors Ups Progression-Free Survival

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Two-year progression-free survival rate 81 percent with sorafenib vs. 36 percent with placebo
Overall

Prevalence of Benzodiazepine Use 12.6 Percent in the United States

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Misuse accounted for 17.2 percent of overall use; highest misuse reported for those aged 18 to 25 years
First-trimester ondansetron use is associated with a small increased risk for oral cleft but no increased risk for congenital malformations or cardiac malformations

Cardiac Malformations Not Up With First-Trimester Ondansetron

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No increased risk observed for congenital malformations; small increased risk seen for oral clefts
The labels of prescription opioid painkillers should advise doctors to consider simultaneously prescribing the opioid overdose antidote naloxone

FDA Advisory Panels: Prescribe Naloxone With Opioid Painkillers

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Federal government urged to make naloxone more widely available, easier to obtain, and cheaper
Chest computed tomography findings may identify risk factors for respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy

Chest CT Can ID Respiratory AE Risk in RA Patients on Biologics

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Findings seen among rheumatoid arthritis patients on long-term biological therapy
Solriamfetol therapy

Solriamfetol Feasible for Sleep Apnea-Related Tiredness

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Phase III trial shows significant improvements in wakefulness over 12 weeks