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Tag: Prescription Drugs

The gout medicine Uloric (febuxostat) carries a higher risk of death than allopurinol

FDA: Gout Drug Uloric Increases Risk of Death

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Medication is associated with increased risk of heart-related death and death from all causes
Maternal exposure to fluconazole during pregnancy may increase the risk for spontaneous abortion

Prenatal Fluconazole Exposure Increases Neonatal Risks

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Any exposure increases spontaneous abortion risk; cardiac septal defects up for use in early pregnancy
Long-term outcomes are more favorable for early intensive treatment versus first-line moderate-efficacy disease-modifying therapy in multiple sclerosis

Early Intensive Treatment May Improve Long-Term MS Outcomes

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Mean five-year change lower in Expanded Disability Status Scale score with early intensive treatment
For first-line therapy of metastatic renal cell carcinoma

Combo Regimens Effective for Tx of Metastatic Renal Cell Cancer

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Two large trials show benefits for pembrolizumab-axitinib and avelumab-axitinib versus sunitinib
Metastasis-free survival is significantly longer among men with nonmetastatic

Darolutamide Slows Spread of Castration-Resistant Prostate Cancer

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Significant survival benefit seen, adverse events similar between darolutamide and placebo
Despite adequate levels of prescriber

Inappropriate Use of Fentanyl Preps Seen Despite Awareness

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Claims data show many prescribed transmucosal immediate-release fentanyl were opioid-nontolerant
For denosumab-treated women with postmenopausal osteoporosis

Rates of Osteonecrosis of the Jaw Low for Denosumab-Treated Women

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Invasive oral procedures associated with increased incidence of ONJ, but rate low overall
Physicians treating certain cancers who consistently receive payments from a cancer drug's manufacturer are more likely to prescribe that drug instead of other treatments

Drug Company Payments Over Time May Influence Rx Practices

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Payment consistency, high amount, compensation payments tied to cancer drug prescribing practices
An expert panel for the U.S. Food and Drug Administration has endorsed a drug for major depressive disorder that is a close relative to ketamine.

FDA Panel Backs Ketamine-Like Drug for Depression

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Esketamine is a nasal spray that targets different pathways in the brain than other antidepressants do
For adults with chronic hepatitis C virus infection

Direct-Acting Antivirals Cut Mortality in Chronic Hepatitis C

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Mortality, hepatocellular carcinoma risk reduced after adjustment for potential confounders