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Bempedoic acid

Adding Bempedoic Acid to Statin Therapy Reduces LDL Cholesterol

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Genetic variants mimicking effect of ATP citrate lyase inhibitors, statins lower LDL-C in same way
A short regimen is noninferior to a long regimen for patients with rifampin-resistant tuberculosis that is susceptible to fluoroquinolones and aminoglycosides

Short Regimen Noninferior for Rifampin-Resistant Tuberculosis

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Short regimen of nine to 11 months noninferior to 20-month regimen following WHO guidelines
Monthly long-acting cabotegravir and rilpivirine are noninferior to daily regimens for patients with HIV-1

Long-Acting Regimen Noninferior to Daily ART for HIV-1

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Monthly long-acting cabotegravir and rilpivirine noninferior in two randomized controlled trials
Treatment with dasotraline (4 mg/day) significantly improves attention-deficit/hyperactivity disorder symptoms in children aged 6 to 12 years

Dasotraline Promising for the Treatment of ADHD in Children

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Once-daily dosing tolerable, may lessen side effects
Almost half of elderly patients newly diagnosed with acute lymphoblastic leukemia do not receive treatment

Only About Half of Elderly Newly Diagnosed With ALL Receive Tx

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53.5 percent receive treatment within 90 days; 32.4 percent receive chemo without tyrosine kinase inhibitors
For hyperphosphatemic patients with chronic kidney disease receiving maintenance hemodialysis

Tenapanor Reduces Elevated Serum Phosphate in CKD

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Adverse events limited to softened stool, modest increase in bowel movement freqeuncy
The U.S. Food and Drug Administration on Tuesday approved the nasal spray medication esketamine -- a relative of the club drug and anesthetic ketamine -- for use against severe depression. Sold as Spravato

FDA Approves Ketamine-Like Drug for Severe Depression

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Drug available through restricted distribution system, must be administered in certified medical office
In 2016

About 360,000 ED Visits Were for Nonmedical Drug Abuse in 2016

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More than half of estimated visits also involved nonpharmaceutical substances, including drugs, alcohol
For patients with multiple actinic keratosis lesions on the head

Fluorouracil Cream Best Choice for Tx of Actinic Keratosis Lesions

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Fluorouracil more effective than imiquimod, methyl aminolevulinate photodynamic tx, ingenol mebutate
A series of interventions introduced through a quality improvement project can increase the frequency of both teratogen education and urine pregnancy screening in patients taking teratogenic medications for rheumatic disease

Program in Peds Rheumatology Clinic Ups Education on Teratogenic Rx

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Findings seen among girls, women of childbearing age prescribed teratogenic meds