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Having a pharmacist in the emergency department significantly shortens the time to administration of treatment to reverse anticoagulation in patients with life-threatening bleeds or the need for urgent procedures

Pharmacist in ED Cuts Time to Tx to Reverse Anticoagulation

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Time to 4F-PCC shorter for patients who have life-threatening bleeding, need urgent procedures
In a socioeconomically vulnerable minority population

Polypill Strategy Promising in Socioeconomically Vulnerable

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Greater reductions in systolic blood pressure, LDL cholesterol levels with polypill in minority population
Patients with chronic coronary artery disease or peripheral artery disease treated with the combination of rivaroxaban and aspirin face a greater risk for bleeding versus patients treated with aspirin alone

Combo Antithrombotic Therapy Increases Bleeding Risk

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Greatest risk seen in first year of treatment, but benefits of combo therapy continue after one year
The rate of off-label ordering of systemic drugs has increased for children

Off-Label Ordering of Systemic Drugs Up for Children

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Over time, off-label orders have increased for antihistamines, several psychotropics
Teens who misuse prescription or illicit opioids might benefit from the opioid treatment medications methadone

Pharmaceutical Treatments for Opioid Abuse May Benefit Teens

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However, evidence is limited on efficacy, safety of medications for opioid use disorder in teens
Acetaminophen use in mid-to-late pregnancy may have an adverse effect on early childhood neurocognitive outcome

Acetaminophen in Pregnancy May Affect Childhood Behavior

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12 variables, mainly features of hyperactive or attentive behavior, tied to acetaminophen use
For adults with noninfectious uveitis

Mycophenolate Mofetil Does Not Top MTX in Noninfectious Uveitis

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Control of inflammation not superior with mycophenolate mofetil versus methotrexate
For patients with heart failure and reduced ejection fraction

Sacubitril-Valsartan Does Not Impact Aortic Stiffness in HFrEF

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But it is linked to improvements in cardiac structure, function including decreases in LVESVI, LVEDVI
Ticagrelor plus aspirin compared with placebo plus aspirin is associated with a lower incidence of ischemic cardiovascular events but a higher incidence of major bleeding among patients with stable coronary artery disease and type 2 diabetes

Benefit, Harm Seen for Ticagrelor Plus Aspirin in Stable CAD With T2DM

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Incidence of ischemic cardiovascular events lower but major bleeding increased versus placebo plus aspirin
Current evidence does not support routine use of haloperidol or second-generation antipsychotics for prevention or treatment of delirium in hospitalized adults

Evidence Says Antipsychotics Do Not Prevent Delirium in Adults

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Evidence also refutes routine use of haloperidol, second-generation antipsychotics for tx of delirium