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Ticagrelor plus aspirin compared with placebo plus aspirin is associated with a lower incidence of ischemic cardiovascular events but a higher incidence of major bleeding among patients with stable coronary artery disease and type 2 diabetes

Benefit, Harm Seen for Ticagrelor Plus Aspirin in Stable CAD With T2DM

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Incidence of ischemic cardiovascular events lower but major bleeding increased versus placebo plus aspirin
Current evidence does not support routine use of haloperidol or second-generation antipsychotics for prevention or treatment of delirium in hospitalized adults

Evidence Says Antipsychotics Do Not Prevent Delirium in Adults

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Evidence also refutes routine use of haloperidol, second-generation antipsychotics for tx of delirium
The U.S. Preventive Services Task Force recommends that clinicians offer risk-reducing medications to women at increased breast cancer risk. These recommendations form the basis of a final recommendation statement published in the Sept. 3 issue of the Journal of the American Medical Association.

USPSTF Advises Meds to Reduce Risk for Primary Breast Cancer

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Offer risk-reducing meds to women at higher risk for breast cancer, low risk for adverse medication effects
Netarsudil ophthalmic solution (0.02 percent; once daily) significantly reduced mean intraocular pressure among patients with open-angle glaucoma or ocular hypertension

Netarsudil Lowers IOP in Glaucoma, Ocular Hypertension

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ROCKET-4 study shows once-daily netarsudil noninferior to twice-daily timolol
Use of dipeptidyl peptidase-4 inhibitors is associated with increased risks for pancreatitis and pancreatic cancer in patients with newly diagnosed type 2 diabetes

Dipeptidyl Peptidase-4 Inhibitors May Up Pancreatic Disease Risk

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Risks for pancreatitis, pancreatic cancer higher in Korean patients with newly diagnosed T2DM
Exposure to opioid maintenance treatment in the womb does not seem to cause additional harm to newborns

Prenatal Exposure to OMT Does Not Worsen Neonatal Outcomes

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Growth parameters similar to those for newborns of women with opioid use disorders during pregnancy
From 2006 to 2016

Prices Spike for Drugs Used to Treat Multiple Sclerosis

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2006-2016 Medicare claims show 10.2-fold, 7.2-fold hikes in pharmaceutical, out-of-pocket spending
For patients with early rheumatoid arthritis and high disease activity

Combo Tx May Improve Disease Control for Some in Early RA

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Improved disease control, remission, functional capacity for TNF or non-TNF plus methotrexate
There is an increased risk for gallbladder- or biliary tract-related events among patients with type 2 diabetes taking liraglutide versus placebo

Liraglutide Ups Risk for Gallbladder, Biliary Tract Events

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Findings consistent for gallbladder stones, cholecystitis with/without gallbladder stones, biliary obstruction
Use of a four-component polypill can effectively reduce the risk for major cardiovascular events

Low-Cost, Fixed-Dose Polypill Reduces Risk for Major CV Events

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Drop in risk for major cardiovascular events even greater for those with high adherence to polypill