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Over-the-counter medications are commonly used in suicide attempts by self-poisoning among young people

OTC Meds Often Used in Drug-Related Suicide Attempts in Youth

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ADHD meds commonly used by those aged 10 to 15 years, while sedative/hypnotics used more by older youth
A triplet combination of therapies (encorafenib

Triplet Tx Ups Survival in BRAF V600E-Mutated Colorectal Cancer

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Overall survival longer for encorafenib, cetuximab, and binimetinib combo versus standard therapy
The addition of abemaciclib to fulvestrant provides a statistically significant and clinically meaningful gain in median overall survival

Drug Combo Extends Survival in Advanced Breast Cancer

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Benefit seen for addition of CDK4/6 inhibitor after progression of disease on endocrine therapy
Ligelizumab appears to be a safe and effective treatment option for chronic spontaneous urticaria

Ligelizumab Safely, Effectively Treats Hives

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Doses of 72 mg or 240 mg tied to complete control of symptoms after 12-week trial
A three-in-one inhaler therapy can improve lung function and reduce asthma attacks in adults with uncontrolled disease

Three-Drug Single Inhaler Treats Uncontrolled Asthma in Adults

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Findings seen in two large international clinical trials comparing three-drug inhaler to two-drug inhaler
Initiation of isoniazid preventive therapy during pregnancy is associated with increased risks versus initiation during the postpartum period

Isoniazid Tx to Prevent TB Ups Risks During HIV+ Pregnancy

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Deferring treatment until after delivery appears to be safer option
Elderly patients with inflammatory bowel disease are at higher risk for adverse events related to the use of thiopurines

Elderly Who Start Thiopurine Tx for IBD Have Higher Risk for AEs

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Advanced age, female gender are independent risk factors for adverse events
Uptitration of drugs for chronic systolic heart failure stops farther away from the recommended dosage for drugs with higher versus lower recommended dosages

Uptitration of Drugs Varies With Target Dosage in Chronic HF

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When target is higher versus lower dosage, uptitration stops further from recommended dosage
For patients with progressive fibrosing interstitial lung diseases

Nintedanib Slows Fibrosing Interstitial Lung Disease

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Nintedanib linked to lower rate of decline in forced vital capacity versus placebo in phase 3 trial
Heart disease is associated with an increased risk for hospital admission for allopurinol-associated severe cutaneous adverse reactions

Heart Disease May Up Risk for Allopurinol-Linked Cutaneous AEs

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Risk for hospital admission increased for allopurinol-associated severe cutaneous adverse reactions