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Among infants breastfed by mothers who are receiving drug therapy for epilepsy

Antiepileptic Drug Exposure Low in Breastfeeding Infants

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Median percentage of infant-to-mother AED concentration ranged from 0.3 to 44.2 percent
Drug interactions between antiretroviral therapy and direct-acting antivirals pose a clinical challenge in patients with HIV/hepatitis C virus coinfection

Nurses Can Help Manage Drug Interactions in HIV/Hep C Treatment

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Administration of simeprevir is more problematic with ART; sofosbuvir has fewest interactions with ART
Automotive assembly plant closures from 1999 to 2016 were associated with increases in opioid overdose mortality

Closures of Automotive Assembly Plants Tied to Opioid OD Deaths

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Increases in opioid overdose mortality largest for non-Hispanic white men aged 18 to 34, 35 to 65 years
Baseline high body mass index is associated with improved survival in patients with non-small cell lung cancer treated with atezolizumab

BMI, Survival Linked in NSCLC Treated With Atezolizumab

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Overall, progression-free survival improved for patients with high BMI; link strongest with high PD-L1 expression
Among patients with metastatic renal cell carcinoma

Tivozanib Bests Sorafenib in Metastatic Renal Cell Carcinoma

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Progression-free survival longer in those receiving tivozanib as third- or fourth-line therapy
New warnings about the risk for dangerous breathing difficulties when gabapentinoids are used with opioids or by certain patients must now appear on product labels

Gabapentinoids, Opioids Combo Carries Risk for Breathing Problems

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Serious breathing problems can occur in patients who use gabapentinoids with opioids or other CNS depressants
For patients with systemic lupus erythematosus

Anifrolumab Improves Response at 52 Weeks in Lupus

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Rate of composite response showing reduced disease activity higher with anifrolumab versus placebo
Misuse/abuse

Misuse of Nonopioid Medications Appears to Be on the Rise in U.S.

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Increases seen for misuse/abuse, suicide attempts, and hospitalizations linked to gabapentin, baclofen
For pregnant women with HIV

Antiretroviral Prescribing in Pregnancy Strays From National Guidelines

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Many prescribed ARVs with insufficient evidence, not recommended for use in pregnant women with HIV
Among patients with Dravet syndrome

Fenfluramine Reduces Convulsive Seizures in Dravet Syndrome

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Drop in monthly frequency of convulsive seizures significantly greater with fenfluramine versus placebo