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For patients with cystic fibrosis with Phe508del-minimal function genotypes

Elexacaftor-Tezacaftor-Ivacaftor Efficacious for Cystic Fibrosis

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Percentage of FEV1 higher at four weeks and through 24 weeks with treatment versus placebo
Most estimates show no differences in effectiveness between classes of antihypertensive agents

Equivalence Seen Between Drug Classes for HTN Monotherapy

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Thiazide, thiazide-like diuretics superior to ACEi; nondihydropyridine calcium channel blockers inferior
Makena

FDA Committee: Makena Should Be Removed From Market

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Drug was approved by FDA in 2011 to reduce risk for preterm birth in at-risk women
For relapsed or refractory acute myeloid leukemia with mutations in the FMS-like tyrosine kinase 3 gene (FLT3)

Gilteritinib Superior in Relapsed, Refractory FLT3-Mutated AML

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Overall survival significantly longer, percentage of remission higher than with salvage chemotherapy
Patients receiving checkpoint inhibitor therapy often have acute kidney injury

Acute Kidney Injury Often Seen With Checkpoint Inhibitor Use

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8 percent of patients receiving checkpoint inhibitor therapy experienced sustained acute kidney injury
In a head-to-head study of mineralocorticoid receptor antagonists

Spironolactone Noninferior in Duchenne Muscular Dystrophy

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Spironolactone noninferior to eplerenone for preserving cardiac contractility in boys with Duchenne
One lot of alprazolam (generic form of Xanax) is being recalled by Mylan Pharmaceuticals Inc. due to potential contamination that poses a risk for infection.

One Lot of Generic Form of Xanax Recalled Due to Potential Contaminate

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So far, Mylan says it has not received any reports of harm caused by the recalled lot
Despite an increase in the overall number of U.S. pharmacies

One in Eight U.S. Pharmacies Closed in 2009 Through 2015

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Closures disproportionately affect independent pharmacies and low-income neighborhoods
Ingestion of prescribed blood pressure-lowering medications at bedtime is associated with a reduction in cardiovascular disease risk

CVD Risk Declines When BP Meds Taken at Bedtime

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Patients routinely taking antihypertensive meds at bedtime have lower risk for CV events, death
Among patients with mild-to-moderate acute traumatic brain injury

Tranexamic Acid Within Three Hours Cuts Some TBI Deaths

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Patients with mild-to-moderate injury treated with tranexamic acid had reduced risk for head injury-related death