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Among patients with metastatic renal cell carcinoma

Tivozanib Bests Sorafenib in Metastatic Renal Cell Carcinoma

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Progression-free survival longer in those receiving tivozanib as third- or fourth-line therapy
New warnings about the risk for dangerous breathing difficulties when gabapentinoids are used with opioids or by certain patients must now appear on product labels

Gabapentinoids, Opioids Combo Carries Risk for Breathing Problems

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Serious breathing problems can occur in patients who use gabapentinoids with opioids or other CNS depressants
For patients with systemic lupus erythematosus

Anifrolumab Improves Response at 52 Weeks in Lupus

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Rate of composite response showing reduced disease activity higher with anifrolumab versus placebo
Misuse/abuse

Misuse of Nonopioid Medications Appears to Be on the Rise in U.S.

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Increases seen for misuse/abuse, suicide attempts, and hospitalizations linked to gabapentin, baclofen
For pregnant women with HIV

Antiretroviral Prescribing in Pregnancy Strays From National Guidelines

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Many prescribed ARVs with insufficient evidence, not recommended for use in pregnant women with HIV
Among patients with Dravet syndrome

Fenfluramine Reduces Convulsive Seizures in Dravet Syndrome

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Drop in monthly frequency of convulsive seizures significantly greater with fenfluramine versus placebo
Federal health officials have unveiled plans to allow prescription drug imports from Canada and other foreign nations.

FDA to Allow States to Import Prescription Drugs From Other Countries

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All imports would have to be FDA-approved, tested to ensure quality, relabeled to meet U.S. labeling requirements
Compared with placebo

Addition of Maintenance Olaparib Slows Advanced Ovarian Cancer

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Benefit substantial for homologous-recombination deficiency positive tumors with, without BRCA mutations
Among patients with moderately severe Parkinson disease

SAE Rate Higher With Nilotinib Versus Placebo in Parkinson Disease

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Exploratory biomarkers altered in response to nilotinib, including drop in hyperphosphorylated tau
Anastrozole is associated with a long-term reduction in breast cancer risk

SABCS: Anastrozole Tied to Lasting Reduction in Breast Cancer Risk

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Breast cancer risk significantly lower at median follow-up of 131 months; effect continued after treatment