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U.S. drug companies have started the new year by raising the prices of hundreds of medications.

Price Hikes for Hundreds of Medications

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Prices of 411 drugs have increased an average of 5 percent
In a new evidence-based clinical practice guideline

Guideline Issued for Testosterone Therapy in Adult Men

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Testosterone recommended for men with sexual dysfunction who want to improve sexual function
For patients with elevated lipoprotein(a) levels and established cardiovascular disease

APO(a)-LRX Found to Reduce Lipoprotein(a) Levels

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Dose-dependent reduction found in patients with elevated lipoprotein(a) levels, cardiovascular disease
A novel cathepsin K inhibitor

MIV-711 No Better Than Placebo for Pain Relief in Knee OA

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But significant reductions seen in medial femoral bone area progression, medial femoral cartilage thinning
For adults with posttraumatic stress disorder

Neither Psychotherapy Nor Medications Favored for PTSD

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Evidence insufficient to determine whether psychotherapy, medications are more effective
A machine learning system can generate clinically valid alerts for medication errors that might be missed with existing clinical decision support systems

Machine Learning System Makes More Alerts for Med Errors

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68.2 percent of MedAware alerts would not have been generated with clinical decision support system
Among infants breastfed by mothers who are receiving drug therapy for epilepsy

Antiepileptic Drug Exposure Low in Breastfeeding Infants

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Median percentage of infant-to-mother AED concentration ranged from 0.3 to 44.2 percent
Drug interactions between antiretroviral therapy and direct-acting antivirals pose a clinical challenge in patients with HIV/hepatitis C virus coinfection

Nurses Can Help Manage Drug Interactions in HIV/Hep C Treatment

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Administration of simeprevir is more problematic with ART; sofosbuvir has fewest interactions with ART
Automotive assembly plant closures from 1999 to 2016 were associated with increases in opioid overdose mortality

Closures of Automotive Assembly Plants Tied to Opioid OD Deaths

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Increases in opioid overdose mortality largest for non-Hispanic white men aged 18 to 34, 35 to 65 years
Baseline high body mass index is associated with improved survival in patients with non-small cell lung cancer treated with atezolizumab

BMI, Survival Linked in NSCLC Treated With Atezolizumab

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Overall, progression-free survival improved for patients with high BMI; link strongest with high PD-L1 expression