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Lopinavir-ritonavir treatment offers no significant benefit over standard care for hospitalized adult patients with severe coronavirus 2019 infection

Lopinavir-Ritonavir No Benefit in Adults With Severe COVID-19

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No benefit seen in time to clinical improvement, mortality at 28 days compared with standard care alone
Patients already prescribed angiotensin-converting enzyme inhibitors or angiotensin receptor blockers should continue taking their medications

Statement Addresses Concerns About Heart Meds and COVID-19

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Patients advised to continue ACE inhibitors/ARBs after researcher posits risk for severe COVID-19 infection
Metformin treatment reduces some obesity measures in children

Metformin Could Reduce Obesity in Children

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Metformin therapy reduces some indices of obesity in children and adolescents, review shows
The flu drug favipiravir is "clearly effective" in treating patients with the novel coronavirus

Chinese Researchers Say Flu Drug Effective Against COVID-19

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Scientists believe that favipiravir blocks the coronavirus from replicating in the body
For patients with atrial fibrillation after percutaneous coronary intervention

Dual Therapy Linked to Lower Bleeding Risk in A-Fib After PCI

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Low-certainty evidence showed inconclusive effects for all-cause mortality, cardiovascular mortality, MI
Use of tenofovir alafenamide-emtricitabine is not cost-effective compared with generic tenofovir disoproxil fumarate-emtricitabine for HIV preexposure prophylaxis among men who have sex with men

New HIV PrEP Drug Not Cost-Effective Compared With Generic

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F/TAF would avert 2,101 fractures, 25 cases of end-stage renal disease, but not deemed cost-effective
In an Endocrine Society guideline update

Romosozumab Added to Guideline for Management of Osteoporosis

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Drug recommended for postmenopausal women at very high fracture risk but not at high risk for heart disease, stroke
Anticholinergic burden is associated with adverse outcomes in a middle- to older-aged population

Anticholinergic Burden Tied to Adverse Effects in Middle Age

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Identification of at-risk populations varies by scale used, which could impact clinical practice
Gabapentin appears to be efficacious for the treatment of alcohol use disorder

Gabapentin Seems Efficacious for Alcohol Use Disorder

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Positive effect seen on heavy drinking days, total abstinence, especially in high alcohol withdrawal group
Adherence to antimalarials may offer a protective effect against type 2 diabetes mellitus among patients with systemic lupus erythematosus

Antimalarials May Cut Risk for Type 2 Diabetes in Lupus Patients

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T2DM risk reduced by 39 percent for those with high adherence to antimalarial therapy for managing lupus