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Age and underlying cardiovascular disease are associated with in-hospital mortality in COVID-19

ACE Inhibitors, ARBs Not Linked to In-Hospital COVID-19 Death

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Risk for in-hospital death increased with age >65, underlying cardiovascular disease, COPD, smoking
In an evidence-based guideline developed by an international team of physicians

Guideline Issued for Nonsevere, Severe COVID-19 Therapy

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Corticosteroids recommended for severe COVID-19 with ARDS but not severe COVID-19 without ARDS
Yoga plus medical care is better than medical therapy alone for the treatment of episodic migraines

Yoga + Medical Care Better for Episodic Migraines

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Improvement seen in headache frequency, intensity, pill count, disability assessments
L-thyroxine does not improve hypothyroid symptoms or tiredness among older adults with subclinical hypothyroidism and high symptom burden

L-Thyroxine Does Not Improve Subclinical Hypothyroidism in ≥65s

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No improvement seen in hypothyroid symptoms, tiredness versus placebo in older adults with SCH
Use of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers and other classes of antihypertensive medications seem not to be associated with COVID-19

ACE Inhibitors, ARBs Not Linked to Risk for COVID-19

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And, not one of five classes of anti-HTN meds linked to increased likelihood of positive COVID-19 test
Recommendations are presented for the management of eosinophilic esophagitis in clinical practice guidelines published in the May issue of Gastroenterology.

Guidelines Issued for Managing Eosinophilic Esophagitis

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Topical glucocorticosteroids recommended over no treatment
Genomic targeted prostate cancer treatment shows a survival benefit in patients with metastatic castration-resistant prostate cancer

Genomically Targeted Treatment Slows Advanced Prostate Cancer

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Men receiving olaparib versus standard treatment experience delayed disease progression
Patients with COVID-19 who receive hydroxychloroquine have a high risk for corrected QT prolongation

Hydroxychloroquine in COVID-19 Ups Risk for QTc Prolongation

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Concurrent treatment with azithromycin linked to greater changes in corrected QT interval
A minor planned decrease in the upper limit of the reference range for thyroid-stimulating hormone (TSH) resulted in an increase in levothyroxine prescriptions and more TSH measurements

Testing, Prescribing Increase After Change to TSH Reference Range

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Levothyroxine prescriptions, TSH measurements increased after upper limit of normal for TSH lowered
For patients with atherosclerotic cardiovascular disease and low-density lipoprotein cholesterol ≥70 mg/dL or non-high-density cholesterol ≥100 mg/dL despite statin therapy

Evolocumab Does Not Impact Cognition in Atherosclerotic CVD

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Adding evolocumab to maximally tolerated statin therapy did not affect patient-reported cognition