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The treatment effects of early comprehensive disease-modifying pharmacological therapy are considerable for patients with heart failure with reduced ejection fraction

Disease-Modifying Drug Regimen May Offer Benefit in Heart Failure

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Lower risk for cardiovascular death or hospital admission seen in HF with reduced ejection fraction
Hydroxychloroquine and azithromycin may have a serious adverse impact on the cardiovascular system

CV Toxicity Tied to Azithromycin and/or Hydroxychloroquine

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Risk increased for prolonged QT and/or ventricular tachycardia, including torsades de pointes
Patients initiating hemodialysis often are prescribed opioids and short-acting benzodiazepines

Benzodiazepines, Codispensed Opioids Common in Hemodialysis

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Risk for mortality increased for those receiving short-acting benzodiazepines alone or with opioids
For patients with COVID-19 requiring hospitalization

Hydroxychloroquine Plus Macrolides No Benefit in COVID-19

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Hydroxychloroquine, chloroquine with or without macrolides linked to in-hospital mortality, arrhythmia
For adults hospitalized with COVID-19 with lower respiratory tract infection

Remdesivir Beats Placebo for Time to COVID-19 Recovery

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Researchers suggest antiviral agents in combination with other therapeutic approaches may further improve outcomes
The World Health Organization has suspended use of the antimalarial drug hydroxychloroquine in a clinical trial of treatments of COVID-19 after a study revealed that patients taking the drug are at increased risk for death and serious heart problems.

WHO Suspends Testing of Hydroxychloroquine in COVID-19 Patients

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In light of recent findings, hydroxychloroquine arm of WHO global study paused temporarily
The antiobesity medications phentermine and topiramate may help mitigate weight regain after Roux-en-Y gastric bypass surgery

Antiobesity Meds May Curb Weight Regain After RYGB

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Statistical models suggest phentermine, topiramate, combination can slow, prevent weight regain
Clinically important increases in melanoma risk in patients treated with biologic therapy for common inflammatory diseases cannot be ruled out based on current evidence

Melanoma Risk From Biologic Therapy Remains Uncertain

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Systematic literature review and meta-analysis reveal link to increased risk cannot be ruled out
For patients at high risk for or with established cardiovascular disease in primary care

Sex Differences ID’d in Prescription of Cardiovascular Meds

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Women are less likely to be prescribed aspirin, statins, antihypertensive medications, including ACEIs
Hydroxychloroquine does not improve outcomes in COVID-19

Hydroxychloroquine Does Not Improve COVID-19 Pneumonia Outcomes

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Second study shows no benefit versus standard of care in probability of negative conversion by 28 days