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Preexposure prophylaxis is well tolerated by men who have sex with men at episodic risk for HIV while on vacation

Short-Term PrEP Feasible for Men at Risk for HIV on Vacation

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High levels of medication adherence observed; many interested in transitioning to long-term PrEP
Longer duration of bisphosphonate use is associated with an increased risk for atypical femur fracture

Longer Bisphosphonate Use May Up Atypical Femur Fracture Risk

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Rapid decline in atypical fracture risk seen when bisphosphonate discontinued in women ≥50 years
For patients with homozygous familial hypercholesterolemia

Evinacumab Cuts LDL-C Level in Familial Hypercholesterolemia

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LDL-C down at week 24 with evinacumab versus placebo in homozygous familial hypercholesterolemia
Patients with dementia are frequently prescribed central nervous system-active medications

CNS-Active Meds Often Prescribed for Older Adults With Dementia

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Overall, Rx filled for antidepressants in 49.8 percent, opioids in 29.8 percent, anxiolytics in 26.8 percent
There is no clear benefit of bisphosphonates on bone marrow lesions

Bisphosphonates Safe but May Not Improve Bone Marrow Lesion Volume

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However, a trend was seen toward a decrease in bone marrow lesion volume
Overall survival is longer and the incidence of remission is higher among previously untreated

Drug Combo Prolongs Survival in Acute Myeloid Leukemia

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Findings seen for azacitidine + venetoclax in older patients ineligible for intensive chemotherapy
Gilead Sciences has applied to the U.S. Food and Drug Administration for approval for its COVID-19 treatment

Gilead Seeks FDA Approval for Remdesivir

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Trials of the drug show that it can cut recovery time from COVID-19 by nearly a third
In patients who have previously suffered a vertebral fracture

Longer Bisphosphonate Drug Holiday May Up Fracture Risk

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For those with previous vertebral fracture, major osteoporotic fractures increased with holidays >12 months
For patients with type 2 diabetes

Short-Term Risk for Below-Knee Amputation Not Increased With SGLT2i

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Risk for below-knee amputation not increased versus DPP-4 inhibitor use in patients with type 2 diabetes
Among patients with relapsing multiple sclerosis

Relapse Rates Lower With Ofatumumab in Multiple Sclerosis

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Annualized relapse rates lower for ofatumumab versus teriflunomide in two identical phase 3 trials