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Inhibition of sclerostin with romosozumab may increase cardiovascular risk

Inhibition of Sclerostin May Increase Cardiovascular Risk

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SOST genetic variants linked to lower risk for fracture and osteoporosis but higher risk for MI, major CV AEs
Allopurinol does not affect estimated glomerular filtration rate in patients with chronic kidney disease and does not result in a clinically meaningful benefit in kidney outcomes from serum urate reduction among patients with type 1 diabetes and early-to-moderate diabetic kidney disease

Allopurinol Does Not Affect eGFR in Chronic Kidney Disease

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And, serum urate lowering with allopurinol did not affect GFR in T1DM and diabetic kidney disease
Use of tocilizumab to target cytokine release syndrome seems beneficial for patients with COVID-19

Tocilizumab Shows Promise for Treatment of COVID-19

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Tocilizumab improves oxygenation and inflammatory biomarkers, may improve survival in severe disease
In 2015 to 2018

CDC: 10.7 Percent of U.S. Adults Used Rx Pain Meds in 2015 to 2018

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No change found in use of prescription opioids from 2009-2010 to 2017-2018, but increase seen in nonopioid meds
The occurrence of nephrogenic systemic fibrosis appears to be rare after exposure to newer gadolinium-based contrast agents

Nephrogenic Systemic Fibrosis Rare With Newer GBCA Exposure

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Data scant on exposure to gadolinium-based contrast agents for those with acute kidney injury, risk for CKD
For patients with melanoma treated with immune checkpoint inhibitors (ICIs)

Vitamin D May Cut Colitis Risk for Immune Checkpoint Inhibitors

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Odds of developing ICI colitis significantly reduced with vitamin D use in patients with melanoma
For patients with chronic low back pain

Tanezumab Improves Pain, Function in Chronic Low Back Pain

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Low back pain intensity at week 16 was improved with tanezumab 10 mg versus placebo
An inhaled version of the antiviral drug remdesivir will soon be tested outside a hospital setting

Inhaled Remdesivir May Allow COVID-19 Patients to Be Treated at Home

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Currently, the drug has to be given intravenously through daily infusions in the hospital
The U.S. government does not have the legal authority to force drug companies to disclose prices in their TV ads

Court Rules Against Drug Price Disclosures in TV Ads

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Judges said HHS exceeded its legal authority by requiring drug price disclosure as part of its stewardship of Medicare, Medicaid
Cardioprotective therapies

Cardioprotective Therapy Use Lower With Cancer History

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Utilization rate of antiplatelet therapies and statins significantly lower for patients with cancer history