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There is no clear benefit of bisphosphonates on bone marrow lesions

Bisphosphonates Safe but May Not Improve Bone Marrow Lesion Volume

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However, a trend was seen toward a decrease in bone marrow lesion volume
Overall survival is longer and the incidence of remission is higher among previously untreated

Drug Combo Prolongs Survival in Acute Myeloid Leukemia

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Findings seen for azacitidine + venetoclax in older patients ineligible for intensive chemotherapy
Gilead Sciences has applied to the U.S. Food and Drug Administration for approval for its COVID-19 treatment

Gilead Seeks FDA Approval for Remdesivir

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Trials of the drug show that it can cut recovery time from COVID-19 by nearly a third
In patients who have previously suffered a vertebral fracture

Longer Bisphosphonate Drug Holiday May Up Fracture Risk

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For those with previous vertebral fracture, major osteoporotic fractures increased with holidays >12 months
For patients with type 2 diabetes

Short-Term Risk for Below-Knee Amputation Not Increased With SGLT2i

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Risk for below-knee amputation not increased versus DPP-4 inhibitor use in patients with type 2 diabetes
Among patients with relapsing multiple sclerosis

Relapse Rates Lower With Ofatumumab in Multiple Sclerosis

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Annualized relapse rates lower for ofatumumab versus teriflunomide in two identical phase 3 trials
For patients with severe COVID-19

Early Use of IL-6 Inhibitors May Improve COVID-19 Outcomes

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Mortality, risk for intubation lower with IL6ri use in severe COVID-19 stage IIB versus stage III
Individuals of Hispanic/Latino background with known peripheral artery disease have the lowest use of all classes of cardiovascular medications

CV Meds Underused in Hispanics With Peripheral Artery Disease

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For all classes of cardiovascular medications, lowest use seen for individuals of Mexican background
Sprint and strength performance are improved in nonasthmatic athletes by using β2-agonists

β2-Agonists Improve Nonaerobic Athletic Performance

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Specifically, sprint and strength performance were enhanced with use of β2-agonists
More than one-third of stroke survivors have uncontrolled hypertension

More Than One in Three Stroke Survivors Have Uncontrolled HTN

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80.4 percent of stroke survivors take antihypertensive medications, most commonly ACEi, ARB