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In a 2020 American Diabetes Association clinical guideline

ADA Updates Guideline for Pharmacotherapy of T2DM

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Metformin preferred as initial agent; early combined therapy can extend time to treatment failure
About half of waivered clinicians prescribe buprenorphine for opioid use disorder and most treat at levels below their patient limits

About Half of Waivered Clinicians Prescribe Buprenorphine for OUD

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Percentages much higher for actively prescribing U.S. clinicians with 275 and 100 versus 30 patients
An electronic alert may reduce excessive prescribing of short-acting beta2 agonists among patients with asthma in primary care

Electronic Alert May Cut Excessive SABA Prescribing in Asthma

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Repeat SABA prescribing for patients with asthma decreased in the 12 months following the alert
Nine individual antihypertensive agents from the classes of angiotensin agents

Antihypertensive Agents Not Tied to Higher Risk for Depression

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Depression rates down with nine antihypertensive agents, including enalapril, amlodipine, atenolol
Renin-angiotensin-aldosterone system inhibitors are beneficial for hypertensive patients with COVID-19

RAAS Inhibitors May Benefit HTN Patients With COVID-19

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Risk for death, death/critical outcomes lower with use of RAAS inhibitors for hypertension
Patients with moderate COVID-19 receiving a five-day course of remdesivir have a statistically significant difference in clinical status compared with usual care

Clinical Impact of Remdesivir in Moderate COVID-19 Unclear

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Significant difference seen in clinical status versus usual care for five-day, but not 10-day, course
Preexposure prophylaxis is well tolerated by men who have sex with men at episodic risk for HIV while on vacation

Short-Term PrEP Feasible for Men at Risk for HIV on Vacation

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High levels of medication adherence observed; many interested in transitioning to long-term PrEP
Longer duration of bisphosphonate use is associated with an increased risk for atypical femur fracture

Longer Bisphosphonate Use May Up Atypical Femur Fracture Risk

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Rapid decline in atypical fracture risk seen when bisphosphonate discontinued in women ≥50 years
For patients with homozygous familial hypercholesterolemia

Evinacumab Cuts LDL-C Level in Familial Hypercholesterolemia

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LDL-C down at week 24 with evinacumab versus placebo in homozygous familial hypercholesterolemia
Patients with dementia are frequently prescribed central nervous system-active medications

CNS-Active Meds Often Prescribed for Older Adults With Dementia

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Overall, Rx filled for antidepressants in 49.8 percent, opioids in 29.8 percent, anxiolytics in 26.8 percent