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The U.S. Food and Drug Administration is requiring labeling changes to nonsteroidal anti-inflammatory drugs that warn of the risks of taking these drugs at 20 weeks of pregnancy or later

FDA Requiring Labeling Changes to NSAIDs Warning of Risks in Pregnancy

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Labeling must indicate risks to unborn baby with NSAID use at 20 weeks of pregnancy or later
Ertugliflozin is noninferior to placebo with respect to major adverse cardiovascular events among patients with type 2 diabetes and atherosclerotic cardiovascular disease

Ertugliflozin Noninferior for CV Outcomes in T2DM With ASCVD

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Ertugliflozin is noninferior to placebo for the primary end point of major adverse cardiovascular events
Polypharmacy

Polypharmacy Common in Seniors With Heart Failure

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With increasing number of medications, more rapid increase seen in number of noncardiovascular meds
A study to assess whether certain approved or experimental drugs are effective against COVID-19 and warrant testing in large clinical trials has been launched by the U.S. National Institutes of Health (NIH).

NIH Launches Trial of Antibody Drugs Against COVID-19

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The phase 2 trial will assess effectiveness of monoclonal antibodies in conjunction with remdesivir
Enrollment in a study testing an experimental antibody therapy against COVID-19 has been paused by independent monitors.

COVID-19 Antibody Treatment Study Paused

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ACTIV-3 study, testing use of an antibody therapy with remdesivir, paused 'out of an abundance of caution'
Evidence-based guidelines successfully reduce postoperative opioid prescribing without increased refill rates

One Size May Not Fit All for Postoperative Opioid Prescribing

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Guidelines reduce postoperative opioid prescribing but may result in inadequate pain control for some
For patients hospitalized with COVID-19

Remdesivir Cuts Time to COVID-19 Recovery

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However, no significant difference in mortality found between remdesivir and placebo groups
The majority of older adults who take multiple medications have never had a comprehensive medication review

Poll: Medication Management Lacking in Older Adults

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Most older adults taking multiple medications have never had a comprehensive medication review
Regeneron Pharmaceuticals Inc. said Wednesday that it is seeking emergency approval from the U.S. Food and Drug Administration for an experimental antibody cocktail given to President Donald Trump shortly after he was diagnosed with COVID-19.

Maker of Antibody Cocktail Trump Took Seeks Emergency Use Authorization

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Although effectiveness has not yet been seen in humans, drug has shown promise in treating mild cases of COVID-19
Lopinavir-ritonavir is not associated with reductions in 28-day mortality or duration of hospital stay among patients admitted to the hospital with COVID-19

Lopinavir-Ritonavir No Benefit in Patients Admitted With COVID-19

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No reductions seen in 28-day mortality or duration of hospital stay in COVID-19 with lopinavir-ritonavir