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Links Explored for ADHD Meds, Externalizing Symptoms, Child Suicidality

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ADHD medications may moderate the association between externalizing symptoms and risk for suicidality in children

ASCO: Sotorasib Targets KRAS p.G12C-Mutated NSCLC

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Objective response seen in 37.1 percent of patients with previously treated KRAS p.G12C-mutated non-small cell lung cancer

Buprenorphine Rx Activity Varies Widely Among Clinicians

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Less than 5 percent of prescribers account for half of all buprenorphine treatment in the country

ACC: Ultrasound Renal Denervation Cuts BP in Med-Resistant HTN

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Reduction in daytime ambulatory systolic blood pressure at two months greater with ultrasound renal denervation versus sham procedure

Upadacitinib Treats Moderate-to-Severe Atopic Dermatitis

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Two replicate double-blind, randomized, placebo-controlled trials show short-term efficacy for upadacitinib in adolescents and adults

CDC: Self-Administered Subcutaneous DMPA Should Be Made Available

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WHO recommendation adopted based on evidence that self-administered DMPA-SC is safe, effective with higher continuation rates

Meds Used for Hospitalized COVID-19 Patients Shifted Over 2020

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Dexamethasone and remdesivir use grew substantially, while azithromycin and hydroxychloroquine both declined from early peaks

Key Factors ID’d for Bipolar Medication Nonadherence

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Patients report side effects, beliefs, and knowledge about bipolar disorder are top reasons for not taking medications

Intensive BP Lowering Cuts Major Adverse CV Events, Mortality

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But adverse effects, including hypotension, acute kidney injury, syncope, more frequent with intensive treatment in those at increased CV risk

Rituximab, Mycophenolate Mofetil Compared for Pemphigus Vulgaris

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More patients receiving rituximab versus mycophenolate mofetil had sustained complete remission at week 52, fewer had disease flares