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$345 Million Settlement Proposed in EpiPen Lawsuits

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Pfizer spokesperson denied any wrongdoing and said settlement was sought to avoid 'the distraction of continued litigation'

High-Dose Buprenorphine Induction in ED Seems Safe for Treating OUD

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High-dose buprenorphine protocol well tolerated in patients with untreated opioid use disorder; no reports of respiratory depression or sedation

Adding Ipilimumab to Nivolumab No Better in Pretreated Squamous NSCLC

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No difference in overall survival seen with nivolumab plus ipilimumab, nivolumab alone for advanced, chemotherapy-pretreated disease

Neutralizing Monoclonal Antibody Combo Treats Mild, Moderate COVID-19

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For those at high risk, COVID-19-related hospitalization or death from any cause reduced with bamlanivimab/etesevimab versus placebo

Ruxolitinib Best for Glucocorticoid-Refractory, -Dependent GVHD

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Overall response, failure-free survival, symptom response significantly greater with ruxolitinib versus control therapy

Two Major Health Systems Will Not Administer Controversial Aduhelm

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Individual doctors can prescribe Aduhelm, but patients would have to go elsewhere to receive the drug via infusion

Rx Treatment for Opioid Use Disorder Up Among Medicaid Enrollees

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There are still considerable gaps in medication care, with Black enrollees having lower use than Whites

High-Efficacy Therapy May Reduce Relapses in Active SPMS

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But no difference in disability progression seen for high-efficacy versus low-efficacy therapy for secondary progressive multiple sclerosis

Neither Remdesivir Nor HCQ Affect Viral Clearance in COVID-19

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No significant difference seen for in-hospital mortality among those receiving remdesivir, hydroxychloroquine, standard of care

Medicare Mulls Coverage for Controversial Drug for Alzheimer Disease

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CMS says a final decision on coverage is not likely until next spring