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Most Immunosuppressive Meds Not Tied to Worse COVID-19 Outcomes

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Except for rituximab, no increased risk seen for in-hospital death or mechanical ventilation for those on long-term immunosuppressive therapy

Giving Nivolumab/Ipilimumab First Ups Overall Survival in Melanoma

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Two-year overall survival 72 percent for those starting with N/I, 52 percent for those starting with dabrafenib/trametinib

Colchicine No Benefit Over Supportive Care for COVID-19

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No significant reduction reported in mortality, ventilatory support, ICU admission, length of stay, serious adverse events; increase seen in adverse events, diarrhea

FDA Panel Mulls Merck COVID-19 Antiviral Pill

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Expert panel will vote later Tuesday on whether to recommend authorizing the drug for high-risk patients

Regeneron Says Its Antibody Cocktail Likely Weakened by Omicron Variant

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No direct data yet available testing the new variant's resistance to immunity from monoclonal antibodies and vaccines

Merck’s COVID-19 Pill Appears Effective, but May Pose Pregnancy Risks: FDA

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Given safety concerns, FDA scientists said Merck has agreed the drug will not be used in children.

Dasatinib Beneficial in Type 2 Diabetes

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Patients treated with dasatinib had mean reduction in serum glucose concentration and relative decrease in body weight

Guidance Updated on Treating Motor Symptoms in Early Parkinson Disease

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Levodopa preferred as initial dopaminergic therapy for motor symptoms in patients with early Parkinson disease

Outpatient Gabapentin Rarely Used for Approved Indications

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Concomitant use of central nervous system-depressant drugs listed for 58.4 percent of off-label gabapentin visits

Ethical Considerations Explored for Aducanumab in Alzheimer Disease

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Grounds insufficient to offer aducanumab for moderate, advanced Alzheimer dementia or patients without biomarker evidence of brain ß-amyloid