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Cemiplimab Prolongs Survival in Recurrent Cervical Cancer

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Overall survival longer with cemiplimab versus single-agent chemo for recurrent disease after first-line platinum-containing chemo

Methotrexate-Related AEs Profiled in Early Rheumatoid Arthritis

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Adverse events common during first year of methotrexate therapy for early rheumatoid arthritis, but most not serious

Trametinib Slows Recurrent Low-Grade Serous Ovarian Carcinoma

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Median progression-free survival significantly prolonged with trametinib versus one of five standard-of-care treatment options

Dry Powder Inhalers Show Benefits for Asthma Control, Environment

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Switching to dry powder inhaler more than halves carbon footprint of asthma treatment without asthma worsening

ASA: Less Bleeding Seen With Tenecteplase for Ischemic Stroke

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Rate of symptomatic intracranial hemorrhage lower with tenecteplase than the current standard medication for thrombolysis, alteplase

Daridorexant Safe, Effective for Insomnia Disorder

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50-mg dose shows significant improvement versus placebo for sleep onset, sleep maintenance, and total sleep time

Ketamine Fast Acting, Effective for Suicidal Ideation

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63.0 percent of patients reached full remission at day three; remission remained high at 69.5 percent at week six

Racial Disparity Seen in Initiation of Newer Diabetes Meds

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Significantly lower rates of initiation seen in Black and American Indian or Alaskan Native individuals

Remdesivir Offers Some Benefit for Hospitalized COVID-19 Patients

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No difference seen for in-hospital mortality, but need for initiation of mechanical ventilation reduced with addition of remdesivir to standard care

Polygenic Score Helps Guide Choice of Chemo for Pediatric AML

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Polygenic score based on single nucleotide polymorphisms in the ara-C pathway genes may predict treatment outcomes