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New Malaria Treatment Gets First Approval for Use in Children

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Single dose of tafenoquine is for use in combination with the traditional malaria drug chloroquine

Adding Ribociclib to Letrozole Prolongs Survival in Advanced Breast Cancer

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Reduced risk for death seen with letrozole plus ribociclib versus placebo in postmenopausal women with HR-positive, HER2-negative disease

Nonantibiotic Prophylaxis Noninferior for Recurrent UTI

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Incidence of antibiotic-treated UTI during 12-month treatment period noninferior for methenamine hippurate versus prophylactic antibiotics

Pfizer Begins Trial of COVID-19 Drug Paxlovid in Children 6 to 17 Years

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Trial will assess safety and efficacy in children with confirmed infection who are not hospitalized but are at risk for severe disease

Molnupiravir for Nonsevere COVID-19 Added to Living Guideline

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Molnupiravir recommended only for those at highest risk for hospitalization given its potential long-term harms

Nirsevimab Protects Against RSV in Late-Preterm, Term Infants

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Single injection administered before RSV season protects from medically attended RSV-associated lower respiratory tract infection

AAN Issues Review of Evidence for Aducanumab in Alzheimer Disease

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Class I study shows single doses of aducanumab safe, well tolerated; class II studies show reduced amyloid deposition on brain PET at one year

Overdose Deaths From Non-BZD Hypnotics/Sedatives Up in the U.S.

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Proportion of overdose deaths involving these drugs increased more than threefold between 2000 and 2018

ACP Issues Final Practice Points for Remdesivir Use in COVID-19

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Consider treatment with remdesivir for five days for hospitalized COVID-19 patients who do not require invasive ventilation or ECMO

AAAAI: Add-On Inhaled Glucocorticoid Lowers Severe Asthma Exacerbations

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Adding inhaled glucocorticoid to usual care beneficial for Black and Latinx adults with moderate-to-severe asthma