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Approved-Label Populations for New Drugs Broader Than Trial Populations

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Inconsistency seen most often in terms of patient fitness, with variance in almost all approved indications

Kerendia Approved for Heart Failure With Left Ventricular Ejection Fraction ≥40 Percent

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Patients taking Kerendia saw significant reduction in cardiovascular death and hospitalization and urgent visits for heart failure

Gabapentin for Back Pain Linked to Increased Risk for Dementia, MCI

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Further increase in risk was seen with prescription frequency, with higher risk for 12 or more prescriptions

Hypercholesterolemia Treatment Falls Short of Guidelines

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In recent study, 23 percent of NHANES primary prevention cohort currently using lipid-lowering therapies versus 47 percent eligible under U.S. guidelines

Preschool Depression Intervention Has Long-Term Beneficial Effects

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Those with remission at preadolescence have lower lifetime use of antipsychotics and intensive mental health interventions

NRTI Use Linked to Risk for Primary Open-Angle Glaucoma

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Increased risk seen in adjusted analyses in association with nucleoside and nucleotide reverse transcriptase inhibitor use

Suspected Pharmacologic Triggers Do Not Appear to Cause Microscopic Colitis

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No evidence of causal relationship seen between previously suspected medications and risk for microscopic colitis

Review Compares Efficacy, Safety of Treatments for Hidradenitis Suppurativa

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Differences between adalimumab and other targeted treatments mainly not significant

FDA Will Now Require Labeling of ADHD Medication to Indicate Weight Loss Risk

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Agency will require a Limitation of Use section in the prescribing information of all extended-release ADHD stimulants

ADHD Medications Remain Linked to Lower Risk for Real-World Adverse Outcomes

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Magnitude of these associations decreases alongside increasing prescription rates