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Many U.S. adults

Survey: Many U.S. Adults Not Planning to Get Flu Vaccine

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Vaccine knowledge and anticipated rates of vaccination even lower for pneumococcal disease
Overuse of broad-spectrum antibiotics is associated with increased mortality and other poor outcomes in adults admitted for community-onset pneumonia

Poor Pneumonia Outcomes Tied to Overuse of Broad-Spectrum Antibiotics

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Poor outcomes include higher mortality, longer hospital stay, and greater risk for C. difficile infection
Patients hospitalized with pneumonia often receive excess antibiotic therapy

Hospitalized Pneumonia Patients Often Get Excess Antibiotics

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Vast majority of excess treatment occurs with antibiotics prescribed at discharge
Medicare Advantage patients have higher risk-adjusted hospital readmission rates than traditional Medicare patients for acute myocardial infarction

Medicare Advantage Patients Have Higher Readmission Rates

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Higher adjusted readmission rates seen for AMI, CHF, pneumonia with Medicare Advantage
The recommended maximum age for male HPV vaccination should be raised from 21 to 26 years

ACIP: Men as Old as 26 Should Get HPV Vaccine

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Panel also no longer advises that healthy Americans ≥65 routinely receive Prevnar 13 vaccination
Children with community-acquired pneumonia often receive diagnostic testing and antibiotic therapy despite publication of guidelines against their routine use in 2011

Diagnostic Testing, Antibiotics Overused in Pediatric CAP

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Chest radiography ordered in 43 percent, antibiotics prescribed in 73.9 percent of community-acquired pneumonia visits
Zerbaxa (ceftolozane and tazobactam) has been approved for a new indication to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia in patients aged 18 years and older

Zerbaxa Approved for Hospital-Acquired Bacterial Pneumonia

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Drug previously approved for treatment of complicated intra-abdominal infections, UTIs
Antiepileptic drug use may increase the risk for pneumonia in patients with Alzheimer disease

AEDs Tied to Higher Pneumonia Risk in Alzheimer Patients

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Risk for pneumonia highest within first month of antiepileptic drug use but persists through two years
Recommending pneumococcal vaccination for all 50-year-olds prevents the most disease in underserved minorities and the general population

Pneumococcal Vaccination at Age 50 Prevents the Most Disease

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But cost of giving pneumococcal vaccines to all 50-year-olds exceeds $250,000 per QALY
Omadacycline is noninferior to moxifloxacin for community-acquired bacterial pneumonia and noninferior to linezolid for acute bacterial skin infections

Omadacycline Noninferior to Moxifloxacin for Pneumonia

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Second study shows noninferiority to linezolid for acute bacterial skin and skin-structure infections