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Higher daily average inpatient pain scores and higher postoperative opioid consumption are associated with a subsequent persistent opioid use of up to six months among pediatric patients undergoing major oncologic surgery

Factors ID’d for Persistent Opioid Use After Pediatric Surgery

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Findings in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemo
From 2001 to 2016 there was an increase in the number and percentage of opioid-related deaths; in addition

Studies ID Impact of U.S. Opioid-Related Mortality, Rx Patterns

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Burden of deaths up; most patients receiving opioid analgesics use immediate-release formulations
The widespread shortages of injectable opioids and small-volume parenteral solutions are jeopardizing patient care and placing a strain on hospital operations

ASHP: SVP, Injectable Opioid Shortages Threaten Patient Care

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98.4 percent of respondents report moderate, severe shortages of morphine, hydromorphone, fentanyl
The widespread shortages of injectable opioids and small-volume parenteral solutions are jeopardizing patient care and placing a strain on hospital operations

ASHP: SVP, Injectable Opioid Shortages Threaten Patient Care

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98.4 percent of respondents report moderate, severe shortages of morphine, hydromorphone, fentanyl
Patterns of potential opioid misuse are positively associated with subsequent opioid overdose

Patterns of Potential Misuse Help Assess Risk of Opioid Overdose

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Positive link for subsequent opioid overdose with greater numbers of prescribers and pharmacies
Patients undergoing urological procedures use just over half of their initial prescription of opioids

AUA: Many Have Unused Opioids After Urologic Procedures

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Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy
Lucemyra (lofexidine hydrochloride) has been approved by the U.S. Food and Drug Administration to treat symptoms of opioid withdrawal.

FDA Approves Non-Opioid Treatment for Opioid Withdrawal

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Lucemyra is an oral selective alpha 2-adrenergic receptor agonist
An intervention targeting the use of intravenous opioids may reduce opioid exposure

Practice Intervention Targeting IV Opioids May Cut Exposure

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Reduction of 84 percent in intravenous opioid doses, and a 55 percent reduction in all parenteral opioids
There is insufficient evidence available for examining the correlation between prescription drug monitoring programs and non-fatal or fatal overdoses

Evidence Lacking for Impact of PDMPs on Drug Overdoses

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Evidence insufficient that drug monitoring programs increase or decrease opioid overdoses in U.S.
Many patients undergoing elective same-day or inpatient joint and spine surgery have unused opioids at one- and six-month follow-up

Many Patients Have Unused Opioids After Spine, Joint Surgery

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Many patients reported unsafe storage and failure to dispose of opioids at one- and six-month follow-up