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Certain opioids are less effective for postoperative pain in patients taking selective serotonin reuptake inhibitor antidepressants

Certain Opioids Less Effective With SSRI Antidepressants

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Surgical patients on SSRIs + prodrug opioids had higher postsurgical pain 8 weeks postdischarge
Misuse of prescribed opioids is associated with other high-risk drug behaviors

Misuse of Rx Opioids Linked to Other High-Risk Behaviors

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Prescribed opioid misuse strongly tied to other drug use disorders, illegal activity, psychological distress
Parents are conflicted about the use of prescribed opioids in children

Parents Conflicted About Opioid Use in Children

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Most parents know about alternatives to opioids, but just over a third ask about them
Implementation of a novel enhanced recovery after surgery protocol can reduce patients' postoperative opioid requirements after elective spinal or peripheral nerve surgery

ERAS Protocol Can Cut Opioid Use After Spine Surgery

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Decline seen in postoperative opioid requirements after elective spinal, peripheral nerve surgery
States with above-median OxyContin misuse before reformulation of the drug experienced a 222 percent increase in hepatitis C infection rates after reformulation

Hepatitis C Infection Rates Up After OxyContin Reformulation

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222 percent increase in HCV infection rates seen after reformulation in states with above-median misuse
There is substantial variation across states in rates of long-term opioid therapy among patients with advanced osteoarthritis

Long-Term Opioid Use With OA Varies Across States

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Variance not fully explained by differences in access to health care providers or patient characteristics
Opioids may be overprescribed to children after orthopedic surgery for supracondylar humerus fractures

After Elbow Surgery, Children May Be Overprescribed Opioids

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Patients who had supracondylar humerus fracture sx used less than 25 percent of prescribed drugs
Physicians who receive direct pharmaceutical payments for opioid prescribing prescribe more opioids

Direct-to-Doctor Payments May Increase Opioid Prescribing

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Prescribers receiving opioid-specific payments prescribed 8,784 more opioid daily doses per year
The risk for infective endocarditis related to injection drug use increased from 2006 to 2015

Infective Endocarditis Related to Injection Drug Use Rising

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Rise in admissions for infective endocarditis tied to injection drugs paralleled rise in hydromorphone rx
Marketing of opioids to physicians is associated with increased mortality from opioid overdoses

Marketing of Opioids Linked to Increased OD Mortality

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Mortality from opioid overdoses up with increase in marketing value/capita, payments to doctors