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Tag: Multiple Sclerosis

Older individuals with multiple sclerosis report less severe depressive symptoms and better physical quality of life

Lower Levels of Depression, Higher QOL for Older MS Patients

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Individuals aged 55 to 65 years have less severe depressive symptoms, better physical QOL
Brain iron at quantitative magnetic resonance imaging is associated with disability in multiple sclerosis

Brain Iron on MRI Linked to Disability in Multiple Sclerosis

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Lower thalamic susceptibility, higher susceptibility of the globus pallidus linked to clinical disability
Among pediatric patients with relapsing multiple sclerosis

Fingolimod Cuts Multiple Sclerosis Relapses in Pediatric Patients

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Compared with interferon beta-1a, less lesion accumulation seen on MRI but more adverse events
In patients with progressive multiple sclerosis

Ibudilast Appears to Slow Brain Atrophy Progression in MS

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In phase 2 randomized trial, 2.5 ml less brain-tissue loss with ibudilast than with placebo over 96 weeks
The combination of genetics and exposure to organic solvents in paints and varnishes increases the risk of multiple sclerosis

Organic Solvents + Genetics May Increase Risk of Multiple Sclerosis

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Finding of susceptibility seen regardless of smoking status
Brain volume loss has nonlinear dynamics and limited reproducibility as a marker of therapeutic response in multiple sclerosis

Dynamics of Brain Volume Loss Vary With MS Progression

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Limited reproducibility of estimates seen using different imaging methods
Various clinical symptoms precede the diagnosis of multiple sclerosis by several years

Various Clinical Disturbances Precede MS Diagnosis

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Understanding prodromal signs may improve multiple sclerosis identification
The U.S. Food and Drug Administration has expanded its approval of the multiple sclerosis drug Gilenya (fingolimod) to include children aged 10 and older.

FDA Expands Use of MS Drug to Include Children

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Gilenya is the first multiple sclerosis drug approved for children
Guidelines have been developed for use of disease-modifying therapies in multiple sclerosis

Guidelines Developed for Use of Drugs in Multiple Sclerosis

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Guidelines relate to starting, switching, stopping disease-modifying therapies
For patients with secondary progressive multiple sclerosis

Siponimod Cuts Risk of Disability Progression in Multiple Sclerosis

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Reduction in 3-month confirmed disability progression in secondary progressive multiple sclerosis