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Patients with pediatric-onset multiple sclerosis have a more rapid reduction in information-processing efficiency over time in adulthood

Cognitive Consequences Worse for Pediatric-Onset Multiple Sclerosis

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Patients with POMS have more rapid reduction in information-processing efficiency over time
Simvastatin's beneficial effects on clinical outcomes and brain atrophy in patients with multiple sclerosis are largely independent of cholesterol levels

Model Explores How Statins Alter Multiple Sclerosis Outcomes

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Loss of brain volume reduced in patients taking simvastatin independent of effect on cholesterol level
The International Pediatric Multiple Sclerosis Study Group has updated standards for future clinical trials in pediatric multiple sclerosis; the new recommendations were published in the May 28 issue of Neurology.

Recommendations Developed for Pediatric Multiple Sclerosis Trials

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Biological rationale exists for using treatments proven efficacious in adults with MS for pediatric MS
A new anatomic threshold may be useful for identifying unilateral optic nerve lesions in patients with multiple sclerosis

Thresholds Found for Unilateral Optic Nerve Lesions in MS

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Intereye differences for retinal nerve fiber layer and macular ganglion cell + inner plexiform layer useful
The selective Bruton's tyrosine kinase inhibitor evobrutinib at a dose of 75 mg once daily is associated with fewer enhancing lesions during weeks 12 through 24 among patients with relapsing multiple sclerosis

AAN: Oral BTK Inhibitor Superior to Placebo in Multiple Sclerosis

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Fewer enhancing lesions seen in weeks 12 to 24 for 75 mg evobrutinib once daily versus placebo
Nearly one in five patients referred to a multiple sclerosis specialty center are misdiagnosed

Significant Number of Referred Patients Misdiagnosed With MS

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At MS referral centers, almost one in five new patients have been incorrectly diagnosed with the disease
For patients with amyotrophic lateral sclerosis

African-Americans With ALS Survive Longer Than Caucasians

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Difference no longer significant when outcome is death or tracheostomy and invasive ventilation
Cortical lesion development surpasses white matter lesion accrual in multiple sclerosis

Cortical Lesions in Multiple Sclerosis Tracked With 7.0-T MRI

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Development of cortical lesions surpassed that of white matter lesions, linked to neurologic disability
For patients with relapsing-onset multiple sclerosis

Beta Interferon Tied to Lower Mortality in Relapsing-Onset MS

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Increased survival seen with more than three years of beta interferon exposure but not lower exposure
Mineral intake seems not to be associated with the risk for multiple sclerosis among women

Minerals Not Linked to Multiple Sclerosis Risk in Women

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Associations null when women with highest versus lowest intake in quintiles, deciles compared