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MCI, Dementia Risks Up With Increasing Biological Severity of Alzheimer Disease

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Monotonic increase in lifetime risk of MCI, dementia seen with increasing amyloid PET centiloid value among those who were currently cognitively unimpaired

AHA: Optimal Heart Health Linked to Reduced MCI Risk in Type 2 Diabetes

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Lower risk for MCI and dementia also seen with moderate, high cardiovascular health in those with high polygenic risk score

Intranasal Insulin, Empagliflozin Have Promising Effects on Cognition

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Intranasal insulin increased mPACC-5, modulated fractional anisotropy and cerebral blood flow

Insomnia Linked to Cognitive Decline, Cognitive Impairment

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Insomnia linked to faster decline in global cognition scores and increased risk for cognitive impairment in older adults

Alzheimer Disease Associated With Greater Neural Flexibility

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Neural flexibility also predicts dementia transition

Intranasal Administration of PET Radiotracer Delivers Insulin to Multiple Brain Regions

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Elevated standard uptake values were seen for 11 brain regions, including regions that support cognition

Gabapentin for Back Pain Linked to Increased Risk for Dementia, MCI

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Further increase in risk was seen with prescription frequency, with higher risk for 12 or more prescriptions

Triglyceride-Glucose Index May Predict Faster Cognitive Decline in Early Phases of Alzheimer Disease

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High triglyceride-glucose index significantly associated with faster cognitive decline in the MCI-Alzheimer disease subgroup