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Some Americans with type 1 diabetes have cut back on their insulin usage as the cost of the drug nearly doubled over a five-year period.

Insulin Price More Than Doubled in the United States

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Insulin spending rose from about $2,900 in 2012 to about $5,700 in 2016
About one in four patients report cost-related insulin underuse

Cost-Related Insulin Underuse May Affect One in Four Patients

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Patients reporting cost-related underuse more likely to have poor glycemic control
From 2018 to 2030

Insulin Needed for T2DM Tx Set to Increase >20 Percent by 2030

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Using higher HbA1c target in over-75s could increase disability-adjusted life-years by 44.2 percent
For patients with suboptimally controlled type 1 diabetes

Better Glycemic Control With Closed-Loop Insulin Delivery

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Better glycemic control, reduced hypoglycemia risk for T1DM patients with suboptimal glycemic control
Recommendations have been developed by the World Health Organization for treatment intensification in type 2 diabetes. The recommendations were published online Sept. 4 in the Annals of Internal Medicine.

WHO Issues Recommendations for Tx Intensification in T2DM

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Also, recommendations for type of insulin for type 1 and type 2 diabetes in low-resource settings
The increasing cost of insulin is potentially exposing those with diabetes to serious health consequences

Increasing Cost of Insulin Has Serious Health Consequences

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Lowest-priced insulin required to safely, effectively achieve treatment goals should be prescribed
Basal insulin analogues for type 2 diabetes mellitus do not substantially differ in their glucose-lowering effect

Basal Insulin Analogues Similar for Glucose Lowering

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Slight differences in risk for nocturnal hypoglycemia or weight gain exist
Initiation of a basal insulin analog versus human neutral protamine Hagedorn insulin is not associated with reduction in the risk of hypoglycemia-related emergency department visits or hospital admissions

Basal Insulin Analogs Don’t Cut Hypoglycemia-Linked ER Visits

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No reduced risk of hypoglycemia-linked ER visits, admissions for basal insulin analog vs. NPH insulin
The endogenous circadian system

Circadian System, Misalignment Have Distinct Impact on Insulin

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Circadian misalignment affects insulin sensitivity and insulin secretion in humans
An oral insulin formulation has been developed using choline and geranate ionic liquid

Oral Insulin Choline, Geranate Ionic Liquid Shows Promise

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Significant, sustained decrease in blood glucose levels with low insulin doses of 3 to 10 U/kg