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Adding corticosteroids to initial intravenous immunoglobulin seems beneficial for preventing coronary artery abnormalities in high-risk patients with Kawasaki disease

Combination Therapy May Benefit Some With Kawasaki Disease

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Adding corticosteroids to initial IV immunoglobulin may reduce risk for coronary artery abnormalities
For patients with chronic edema of the leg and cellulitis

Compression Therapy Lowers Recurrence of Cellulitis of Leg

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Trial stopped early for efficacy in participants with chronic edema of the leg and recurrent cellulitis
As of July 29

CDC Updates Info on Multisystem Inflammatory Syndrome in Children

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Distinguishing this COVID-19-related syndrome from others can be challenging
Thyroid dysfunction in patients with psoriasis may be associated with inflammation caused by psoriasis

Inflammation Tied to Thyroid Dysfunction With Psoriasis

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Prevalence of thyroid dysfunction high with generalized pustular, erythrodermic psoriasis
Multisystem inflammatory syndrome in children

Multisystem Inflammatory Syndrome in Children Profiled

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Two reports describe characteristics of MIS-C seen in U.S. pediatric health centers, New York state
Children with COVID-19 may present with new neurological symptoms involving the central and peripheral nervous systems

Neurological Symptoms Described in Children With COVID-19

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Neurological symptoms involve central, peripheral nervous system; splenial changes ID'd on imaging
Children presenting with pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 have a wide range of presenting symptoms

Signs, Symptoms Vary Widely for Children Presenting With PIMS-TS

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Pediatric inflammatory multisystem syndrome temporally linked to SARS-CoV-2 is poorly understood
A Kawasaki-like multisystem inflammatory syndrome

Kawasaki-Like Disease More Common in Children of African Ancestry

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Kawasaki-like inflammatory syndrome temporally linked to SARS-CoV-2 marked by GI symptoms
Pediatric patients with COVID-19 rarely have systemic inflammation

Systemic Inflammation Rare in Pediatric COVID-19 Patients

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Level of interleukin 10 increased in moderate versus mild cases; no difference seen in IL6, TNFα, IFN-γ
For patients with granulomatosis with polyangiitis or microscopic polyangiitis

Long-Term Rituximab May Aid in Antibody-Associated Vasculitis

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Relapse rates lower versus placebo in granulomatosis with polyangiitis, microscopic polyangiitis