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Multisystem inflammatory syndrome in children

Multisystem Inflammatory Syndrome in Children Profiled

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Two reports describe characteristics of MIS-C seen in U.S. pediatric health centers, New York state
Children with COVID-19 may present with new neurological symptoms involving the central and peripheral nervous systems

Neurological Symptoms Described in Children With COVID-19

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Neurological symptoms involve central, peripheral nervous system; splenial changes ID'd on imaging
Children presenting with pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 have a wide range of presenting symptoms

Signs, Symptoms Vary Widely for Children Presenting With PIMS-TS

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Pediatric inflammatory multisystem syndrome temporally linked to SARS-CoV-2 is poorly understood
A Kawasaki-like multisystem inflammatory syndrome

Kawasaki-Like Disease More Common in Children of African Ancestry

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Kawasaki-like inflammatory syndrome temporally linked to SARS-CoV-2 marked by GI symptoms
Pediatric patients with COVID-19 rarely have systemic inflammation

Systemic Inflammation Rare in Pediatric COVID-19 Patients

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Level of interleukin 10 increased in moderate versus mild cases; no difference seen in IL6, TNFα, IFN-γ
For patients with granulomatosis with polyangiitis or microscopic polyangiitis

Long-Term Rituximab May Aid in Antibody-Associated Vasculitis

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Relapse rates lower versus placebo in granulomatosis with polyangiitis, microscopic polyangiitis
Converting genotype information into an interpretable probability value for five different inflammatory arthritis-causing diseases could potentially improve the diagnostic efficiency of rheumatic disease

Genetic Data May Up Diagnostic Efficiency for Rheumatic Disease

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Genetic Probability tool (G-PROB) calculates probability for diagnosis based on genetic risk scores
The incidence of Kawasaki-like disease increased after the start of the severe acute respiratory syndrome coronavirus 2 pandemic in the Bergamo province of Italy

Kawasaki-Like Disease Incidence Up After Start of SARS-CoV-2

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Children diagnosed after start of SARS-CoV-2 were older, had higher rate of cardiac involvement
American physicians should watch for a dangerous inflammatory syndrome in children that may be linked to COVID-19 infection

Doctors Should Watch for Pediatric Inflammatory Syndrome With COVID-19

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Epidemiologists are developing a definition of the syndrome that could be released this week
High-dose anakinra

Anakinra May Reduce Systemic Inflammation in COVID-19

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At 21 days, survival was 90 percent in anakinra group versus 56 percent in standard treatment group