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Tag: Heartburn / GERD / Indigestion

Epithelial thickness seems to be a marker for gastroesophageal reflux disease

Epithelial Thickness Is Marker for Gastroesophageal Reflux

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Epithelial thickness is best performing criterion for GERD diagnosis in patients with upper GI symptoms
Advice of regulatory authorities released in 2009 and 2010 regarding safety concerns for concomitant use of clopidogrel and certain proton pump inhibitors (PPIs) was partially followed

Many Still Prescribe Concomitant (Es)omeprazole, Clopidogrel

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Patients on clopidogrel prescribed omeprazole or esomeprazole despite safety warnings
Proton pump inhibitor use is associated with increased risk of developing osteoporosis and osteopenia in femur bones

PPI Use Ups Risk of Osteoporosis, Osteopenia in Femur

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PPI users have reduced mean femoral T-scores, increased frequency of osteoporosis, osteopenia
Proton pump inhibitors increase the risk of nonsteroidal anti-inflammatory drug-induced small bowel injury

PPI Use Ups NSAID-Induced Small Bowel Injury

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Increased risk of small bowel injury for healthy participants treated with celecoxib + PPI
Laparoscopic antireflux surgery and esomeprazole are both beneficial for patients with chronic gastroesophageal reflux disease

Laparoscopic Antireflux Sx May Provide Added Benefits in GERD

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Lasting reduction in esophageal acid reflux with LARS and esomeprazole; greater reduction with LARS
For patients with gastroesophageal reflux disease

Lasting Safety, Efficacy for Magnetic Device in GERD

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Lasting improvements in health-related QoL with magnetic sphincter augmentation device
Patients who regularly use proton pump inhibitors may be at increased risk of developing chronic kidney disease

Proton Pump Inhibitors Tied to Chronic Kidney Disease

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Risk increased the longer people used the medications
Mortality and reoperation rates are very low among working-age patients with severe gastroesophageal reflux disease undergoing primary laparoscopic fundoplication

Mortality Low for Laparoscopic Surgery in Severe GERD

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For patients with severe GERD, low rates of 90- and 30-day mortality and 90-day reoperation
For patients requiring dual antiplatelet therapy

ACC: PPI Tx Also Beneficial for Those on Low-Dose Aspirin

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Gastroprotection with PPI therapy reduced primary GI end point in patients on low-dose aspirin
Use of proton pump inhibitors may be linked to long-term kidney damage

Proton Pump Inhibitors Linked to Chronic Kidney Disease

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While study can't prove cause-and-effect, increasing damage seen as dose rises