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Tag: Heart / Stroke-Related: High Cholesterol

For patients with homozygous familial hypercholesterolemia

Evinacumab Cuts LDL-C Level in Familial Hypercholesterolemia

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LDL-C down at week 24 with evinacumab versus placebo in homozygous familial hypercholesterolemia
Pitavastatin lowers blood total cholesterol

Pitavastatin Effective for Lowering Lipids

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Review shows it is more powerful for LDL cholesterol lowering than atorvastatin, rosuvastatin, and fluvastatin
For patients with atherosclerotic cardiovascular disease and low-density lipoprotein cholesterol ≥70 mg/dL or non-high-density cholesterol ≥100 mg/dL despite statin therapy

Evolocumab Does Not Impact Cognition in Atherosclerotic CVD

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Adding evolocumab to maximally tolerated statin therapy did not affect patient-reported cognition
Overall

2015 to 2018 Saw High Total Cholesterol for 11.4 Percent of U.S. Adults

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Highest prevalence of high total cholesterol in those aged 40 to 59; prevalence similar by race/ethnicity
In a special communication article

Public Policy Recs Updated for Familial Hypercholesterolemia

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Goals include enhancing awareness of familial hypercholesterolemia as a global public health issue
For patients with elevated lipoprotein(a) levels and established cardiovascular disease

APO(a)-LRX Found to Reduce Lipoprotein(a) Levels

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Dose-dependent reduction found in patients with elevated lipoprotein(a) levels, cardiovascular disease
Elevated concentrations of non-high-density lipoprotein cholesterol are associated with an increased long-term risk for atherosclerotic cardiovascular disease

Non-HDL Cholesterol Levels Linked to Long-Term ASCVD Risk

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Fifty percent reduction in non-HDLC concentration linked to reduced risk for CVD event by age 75 years
Elevated concentrations of non-high-density lipoprotein cholesterol are associated with an increased long-term risk for atherosclerotic cardiovascular disease

Non-HDL Cholesterol Levels Linked to Long-Term ASCVD Risk

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Fifty percent reduction in non-HDLC concentration linked to reduced risk for CVD event by age 75 years
For patients with ischemic stroke or transient ischemic attack with evidence of atherosclerosis

AHA: Lower-Target LDL Level Beneficial After Stroke, TIA

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Subsequent risk for CV events lower among patients with ischemic stroke, TIA, evidence of atherosclerosis
Predictors of attaining low-density lipoprotein cholesterol and systolic blood pressure goals have been identified

AHA: Predictors for Meeting LDL-C, SBP Goals ID’d in ISCHEMIA

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Older age, male sex, high-intensity statin use, lower baseline LDL-C predict LDL-C goal attainment