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Home Tags Heart / Stroke-Related: High Cholesterol

Tag: Heart / Stroke-Related: High Cholesterol

The health and economic impact of three cardiovascular disease preventive services varies with demographic characteristics and clinical objectives

Health, Economic Impact of CVD Preventive Services Varies

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Highest health impact for hypertension screening and treatment, lowest for aspirin counseling
Achieving targets of low-density lipoprotein (LDL)

Achieving LDL-Particle Targets Deemed Cost-Effective

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LDL-lowering therapy guided by LDL-P is cost-effective, with greater economic benefits over time
Variants in genes encoding proprotein convertase subtilisin-kexin type 9 and 3-hydroxy-3-methylglutarylcoenzyme A reductase are associated with almost equivalent effects on the risk of cardiovascular events and diabetes per unit decrease in low-density lipoprotein cholesterol level

Similar Effects for PCSK9, HMGCR Variant-Mediated Lower LDL

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Almost equivalent effects on cardiovascular events, diabetes per unit decrease in LDL-cholesterol level
Healthier diets may be a factor in the ongoing decline in cholesterol levels for Americans

Levels of Total, LDL Cholesterol Continue to Fall in the U.S.

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Eliminating trans fats from the U.S. diet may be one factor in this healthy trend
A new injectable medication called inclisiran cuts low-density lipoprotein cholesterol by half or more

AHA: Inclisiran Twice Yearly May Effectively Control Cholesterol

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Injectable medication is a next-level PCSK9 inhibitor
Combining statins with the PCSK9 inhibitor evolocumab can help reduce low-density lipoprotein cholesterol to previously unseen levels

AHA: Evolocumab Can Help Substantially Reduce LDL

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Patients taking evolocumab and statins showed a reduction in arterial plaque volume
For patients with type 1 diabetes

PCSK9, LDL-C Link Only Seen for Patients With Highest HbA1c

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In patients with type 1 diabetes, correlation only seen for those in the highest tertile of HbA1c
Low and high levels of high-density lipoprotein cholesterol are linked to increased mortality risk

Low and High HDL Tied to Increased Risk of Mortality

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Study casts doubt on HDL as an independent cardiovascular disease risk factor
Screening for hypercholesterolemia is feasible at routine child immunization visits in primary care practices

Child-Parent Screening for Hypercholesterolemia Feasible

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Screening feasible in primary care at routine child immunization visits for children aged 1 to 2 years
Treatments other than statins also can effectively reduce cardiovascular risk

Both Statin, Non-Statin Therapies Effective for Lowering LDL

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Dietary changes, other meds, and even surgery can lower cardiovascular risk similarly to statins