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A novel machine learning-derived risk score can predict the risk for heart failure among outpatients with type 2 diabetes mellitus

Risk Tool Can Predict Heart Failure in Patients With Diabetes

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AI model integrates readily available clinical, laboratory, and electrocardiographic data
Uptitration of drugs for chronic systolic heart failure stops farther away from the recommended dosage for drugs with higher versus lower recommended dosages

Uptitration of Drugs Varies With Target Dosage in Chronic HF

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When target is higher versus lower dosage, uptitration stops further from recommended dosage
For patients with heart failure and reduced ejection fraction

Dapagliflozin Lowers Risk for Worsening Heart Failure

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Findings seen among patients with heart failure, reduced ejection fraction, irrespective of diabetes
Use of sodium glucose cotransporter 2 inhibitors for type 2 diabetes is associated with a reduced risk for heart failure

SGLT2 Inhibitors Linked to Lower Risk for Heart Failure

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Risk lower for HF, but not major CV events, compared with new users of DPP4 inhibitors
County-level poverty is strongly associated with heart failure and coronary heart disease mortality

County-Level Poverty Strongly Tied to Heart Failure Mortality

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Poverty linked to heart failure and coronary heart disease mortality; link stronger for heart failure
Mortality rate trends for newly diagnosed heart failure patients indicate that the overall reduction in mortality across all age groups is being hindered by high and increasing rates of noncardiovascular events

Decline in Heart Failure Mortality Rates Offset by Comorbidities

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Treatments focused only on cardiovascular outcomes insufficient for improving heart failure patient survival
For patients with heart failure and reduced ejection fraction

Sacubitril-Valsartan Does Not Impact Aortic Stiffness in HFrEF

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But it is linked to improvements in cardiac structure, function including decreases in LVESVI, LVEDVI
Elevated left ventricular mass is associated with an increased long-term risk for cardiovascular events

LV Hypertrophy Predicts Long-Term Risk for CV Events

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Left ventricular hypertrophy stronger predictor than CAC for CHD death, other CV death, heart failure
Persons living with HIV who are hospitalized with heart failure are at an increased risk for subsequent sudden cardiac death

Poor HIV Control Ups Risk for Sudden Cardiac Death in Heart Failure

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Lower CD4 count, nonsuppressed viral load linked to higher risk for sudden cardiac death in HIV with heart failure
For patients with heart failure

Type 2 Diabetes Associated With Poorer Outcomes in Heart Failure

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Findings include structural abnormalities in the heart, poorer quality of life with T2DM and HF