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Chronic Traumatic Encephalopathy Linked to Repetitive Head Impacts

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Substantial RHI exposure was seen in five of seven brain donors with CTE-neuropathologic change

Traumatic Brain Injury Linked to Heightened Risk for Amyotrophic Lateral Sclerosis

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However, increased risk only seen in the two years following traumatic brain injury

Repetitive Head Impact Exposure Tied to Disruption at Depths of Sulci

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Greater RHI was associated with lower fractional anisotropy and higher orientation dispersion index

Circulating Tumor HPV DNA Can ID HPV+OPSCC Years Before Diagnosis

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Sensitivity of detection increased to 96 percent; maximum lead time increased to 10.3 years with application of machine learning model

Deescalated Radiotherapy Tolerated After Surgery for HPV-Linked Oropharyngeal Cancer

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De-escalated regimen more tolerable than standard of care

Moderate-to-Severe TBI Linked to Malignant Brain Tumor Risk

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Moderate-to-severe traumatic brain injury group had significantly higher risk for developing malignant brain tumors versus mild TBI group

Socioeconomic Deprivation Tied to Neurodegeneration in Combat Athletes

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Thalamus and cerebellar cortex showed significantly lower average volumes in combat athletes with high versus low Area Deprivation Index

Elevated INR in Older Adults on Warfarin May Not Be Tied to Risk for...

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Authors say findings warrant re-examining approach to managing anticoagulation in older adults

Updated Guidance Improves Staging of HPV-Positive Oropharyngeal Cancer

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AJCC9V staging system showed superior hazard consistency, outcome prediction, and balance, but not hazard discrimination

Adding Pembrolizumab to Standard Care Ups Event-Free Survival in Head, Neck Cancer

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Addition of neoadjuvant and adjuvant pembrolizumab to standard care significantly improves event-free survival