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A potential genetic link to a child's higher risk of acute otitis media has been identified

Gene Associated With Risk of Acute Otitis Media

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Finding could point to better treatments
Low-density lipoprotein cholesterol-lowering genetic variants are associated with increased risk of type 2 diabetes

Exposure to LDL-C-Lowering Genetic Variants Ups T2DM Risk

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Meta-analysis shows heterogeneous associations for genes in or near NPC1L1 with type 2 diabetes
In germ cell tumors

TP53, MDM2 Alterations Linked to Cisplatin Resistance in GCT

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TP53, MDM2 alterations predict adverse prognosis in patients with germ cell tumors
Patients with the FTO gene respond to weight-loss strategies as well as those without the gene

FTO Gene Does Not Inhibit Weight Loss Success

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Lifestyle, environment likely play bigger roles when losing weight, researchers say
Pevonedistat

Experimental Drug Shows Promise in Melanoma

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Pevonedistat was effective for inhibiting proliferation of melanoma cell lines in vitro
Fibroblast growth factor 21 genotypes may interact with dietary macronutrient intake to affect central adiposity and body fat composition

FGF21, Dietary Intake Interaction Impacts Adiposity

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FGF21 genotype interacts with dietary carbohydrate/fat intake to affect adiposity, body fat
The original classifications of human epidermal growth factor receptor 2 categorization by fluorescent in situ hybridization have been supported by recent data

Novel Findings Support Original Categorization of HER2

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ASCO-CAP guidelines support categorization of HER2 by FISH status used in BCIRG clinical trials
More than one-quarter of Canadian and Alaskan Inuit have the TBC1D4 mutation resulting in elevated postprandial glucose

TBC1D4 Mutation Common in North American Inuit

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TBC1D4 carriers with prediabetes, type 2 diabetes have increased risk of remaining undiagnosed
Fourteen genes have been identified that may help determine whether a cancer treatment could help a patient

Biomarker Score May Help Predict Response to Cancer Treatment

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Researchers say finding might help identify patients most likely to be helped by chemotherapy, radiation
A common genetic variation significantly increases the odds of asthma in children who've had a severe respiratory illness at a young age

Bronchiolitis Plus Gene Variant Raises Asthma Risk in Children

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Higher risk seen in those with PAI-1 gene variant and serious respiratory infection at a young age