Tag: Genetics
Sisters of Those With Adverse Pregnancy Outcome Also Have Increased CVD Risk
Women with APO and their APO-free sisters both have increased risks relative to unrelated APO-free comparators
Ethnoracial Disparities Seen in Access to Genetic Testing in Pediatric Neurology
White pediatric neurology patients more likely to have completed one or more genetic test than Black patients
No Evidence Found Linking Sickle Cell Trait With Unexplained Sudden Death
No evidence supports physical exertion without rhabdomyolysis or heat injury causing sudden death in sickle cell trait
Rheumatoid Arthritis Causally Linked to Prostate Cancer
No significant associations seen for SLE or AS with prostate cancer or in reverse MR analyses
Genomic Classifier Tests Play Heterogeneous Role in Prostate Cancer Risk Classification
Tests do not consistently influence risk classification or treatment decisions; authors call for well-designed trials on role of GC tests in newly diagnosed PCa
Differences Exist in Precision Oncology Drug Eligibility Among Patient Ancestral Groups
Patients of African ancestry had the lowest precision oncology drug-based clinical actionability from 2019 onward
MEK Inhibition Beneficial for Children With Subset of Severe Hypertrophic Cardiomyopathy
Decrease in mortality, morbidity seen with trametinib for children with RASopathy-associated hypertrophic cardiomyopathy
Candidate Genetic Variants Have Minimal Impact on Opioid Addiction Risk
Fifteen candidate genes account for only 0.40 percent of variation in opioid use disorder risk
Genomics-Informed Model Beneficial for Neurodevelopmental Disorders
Genetic diagnoses result in direct changes in management for patients with a pathogenic or likely pathogenic variant
Certain Risk Factors for MS Linked to Pediatric Brain Volume
MS-polygenic risk score and household parental smoking negatively linked to total brain volume, thalamic volume
